CCR5 deficiency predisposes to fatal outcome in influenza virus infection

A. Falcon*, M. T. Cuevas, A. Rodriguez-Frandsen, N. Reyes, F. Pozo, S. Moreno, J. Ledesma, J. Martínez-Alarcón, A. Nieto, I. Casas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-∆32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-∆32 and evaluated its correlation with patient mortality. CCR5-∆32 patients (17.4%) showed a higher mortality rate than WT individuals (4.7%; P=0.021), which indicates that CCR5-∆32 patients are at higher risk than the normal population of a fatal outcome in influenza infection.

Original languageEnglish
Pages (from-to)2074-2078
Number of pages5
JournalJournal of General Virology
Volume96
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015
Externally publishedYes

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© 2015 The Authors.

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