Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody

Stuart Dowall; Irene Taylor; Paul Yeates; Leonie Smith; Antony Rule; Linda Easterbrook; Christine Bruce; Nicola Cook; Kara Corbin-Lickfett; Cyril Empig; Kyle Schlunegger; Victoria Graham; Mike Dennis; Roger Hewson

doi:10.1016/j.antiviral.2012.11.003

Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody

Stuart Dowall^*, Irene Taylor, Paul Yeates, Leonie Smith, Antony Rule, Linda Easterbrook, Christine Bruce, Nicola Cook, Kara Corbin-Lickfett, Cyril Empig, Kyle Schlunegger, Victoria Graham, Mike Dennis, Roger Hewson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.

Original language	English
Pages (from-to)	108-111
Number of pages	4
Journal	Antiviral Research
Volume	97
Issue number	2
DOIs	https://doi.org/10.1016/j.antiviral.2012.11.003
Publication status	Published - Feb 2013

Keywords

Catheterized
Ebola
Model
Pharmacokinetic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.antiviral.2012.11.003

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Dowall, S., Taylor, I., Yeates, P., Smith, L., Rule, A., Easterbrook, L., Bruce, C., Cook, N., Corbin-Lickfett, K., Empig, C., Schlunegger, K., Graham, V., Dennis, M., & Hewson, R. (2013). Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody. Antiviral Research, 97(2), 108-111. https://doi.org/10.1016/j.antiviral.2012.11.003

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abstract = "Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.",

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Dowall, S, Taylor, I, Yeates, P, Smith, L, Rule, A, Easterbrook, L, Bruce, C, Cook, N, Corbin-Lickfett, K, Empig, C, Schlunegger, K, Graham, V, Dennis, M & Hewson, R 2013, 'Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody', Antiviral Research, vol. 97, no. 2, pp. 108-111. https://doi.org/10.1016/j.antiviral.2012.11.003

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T1 - Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody

AU - Dowall, Stuart

AU - Taylor, Irene

AU - Yeates, Paul

AU - Smith, Leonie

AU - Rule, Antony

AU - Easterbrook, Linda

AU - Bruce, Christine

AU - Cook, Nicola

AU - Corbin-Lickfett, Kara

AU - Empig, Cyril

AU - Schlunegger, Kyle

AU - Graham, Victoria

AU - Dennis, Mike

AU - Hewson, Roger

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AB - Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.

KW - Catheterized

KW - Ebola

KW - Model

KW - Pharmacokinetic

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AN - SCOPUS:84871894016

SN - 0166-3542

VL - 97

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JF - Antiviral Research

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ER -

Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody

Abstract

Keywords

UN SDGs

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