Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024

Muhammad Ibaad Alvi; Merav Kliner; William Welfare; N. Claire Gordon; Sherine Thomas; Simon Padfield; Hannah E. Emmett; Ellen Heinsbroek; Gareth J. Hughes; Natalie Groves; Eileen Gallagher; Steven Pullan; Amy Belfield; Catherine F. Houlihan; Tommy Rampling; Geraldine O'Hara; Anne Tunbridge; Jake Dunning; Elizabeth Whittaker; Alejandra Alonso; Mike Beadsworth; Brendan Ai Payne; Meera Chand; Susan Hopkins; Gillian Armstrong

doi:10.2807/1560-7917.ES.2025.30.10.2500131

Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024

Muhammad Ibaad Alvi^*, Merav Kliner, William Welfare, N. Claire Gordon, Sherine Thomas, Simon Padfield, Hannah E. Emmett, Ellen Heinsbroek, Gareth J. Hughes, Natalie Groves, Eileen Gallagher, Steven Pullan, Amy Belfield, Catherine F. Houlihan, Tommy Rampling, Geraldine O'Hara, Anne Tunbridge, Jake Dunning, Elizabeth Whittaker, Alejandra AlonsoMike Beadsworth, Brendan Ai Payne, Meera Chand, Susan Hopkins, Gillian Armstrong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN. Three household contacts of the first individual, including two children, became infected. These are the first reported autochthonous transmissions of clade Ib in Europe, and first paediatric cases outside the African continent.

Original language	English
Article number	2500131
Journal	Eurosurveillance
Volume	30
Issue number	10
DOIs	https://doi.org/10.2807/1560-7917.ES.2025.30.10.2500131
Publication status	Published - 13 Mar 2025

Bibliographical note

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© 2025 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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10.2807/1560-7917.ES.2025.30.10.2500131

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Alvi, M. I., Kliner, M., Welfare, W., Gordon, N. C., Thomas, S., Padfield, S., Emmett, H. E., Heinsbroek, E., Hughes, G. J., Groves, N., Gallagher, E., Pullan, S., Belfield, A., Houlihan, C. F., Rampling, T., O'Hara, G., Tunbridge, A., Dunning, J., Whittaker, E., ... Armstrong, G. (2025). Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024. Eurosurveillance, 30(10), Article 2500131. https://doi.org/10.2807/1560-7917.ES.2025.30.10.2500131

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abstract = "We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN. Three household contacts of the first individual, including two children, became infected. These are the first reported autochthonous transmissions of clade Ib in Europe, and first paediatric cases outside the African continent.",

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Alvi, MI, Kliner, M , Welfare, W, Gordon, NC, Thomas, S, Padfield, S, Emmett, HE, Heinsbroek, E , Hughes, GJ , Groves, N, Gallagher, E, Pullan, S, Belfield, A, Houlihan, CF, Rampling, T, O'Hara, G, Tunbridge, A, Dunning, J, Whittaker, E, Alonso, A, Beadsworth, M, Ai Payne, B, Chand, M , Hopkins, S & Armstrong, G 2025, 'Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024', Eurosurveillance, vol. 30, no. 10, 2500131. https://doi.org/10.2807/1560-7917.ES.2025.30.10.2500131

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AU - Alvi, Muhammad Ibaad

AU - Kliner, Merav

AU - Welfare, William

AU - Gordon, N. Claire

AU - Thomas, Sherine

AU - Padfield, Simon

AU - Emmett, Hannah E.

AU - Heinsbroek, Ellen

AU - Hughes, Gareth J.

AU - Groves, Natalie

AU - Gallagher, Eileen

AU - Pullan, Steven

AU - Belfield, Amy

AU - Houlihan, Catherine F.

AU - Rampling, Tommy

AU - O'Hara, Geraldine

AU - Tunbridge, Anne

AU - Dunning, Jake

AU - Whittaker, Elizabeth

AU - Alonso, Alejandra

AU - Beadsworth, Mike

AU - Ai Payne, Brendan

AU - Chand, Meera

AU - Hopkins, Susan

AU - Armstrong, Gillian

PY - 2025/3/13

Y1 - 2025/3/13

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Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024

Abstract

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