Case Report: Toxigenic Corynebacterium ulcerans Diphtheria-Like Infection in a Horse in the United Kingdom

Flavia Zendri; Cajsa Marie Isgren; Matthew Sinovich; Peter Richards-Rios; Katie L. Hopkins; Katherine Russell; Natalie Groves; David Litt; Norman Fry; Dorina Timofte

doi:10.3389/fvets.2021.650238

Case Report: Toxigenic Corynebacterium ulcerans Diphtheria-Like Infection in a Horse in the United Kingdom

Flavia Zendri, Cajsa Marie Isgren, Matthew Sinovich, Peter Richards-Rios, Katie L. Hopkins, Katherine Russell, Natalie Groves, David Litt, Norman Fry, Dorina Timofte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

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Abstract

Corynebacterium ulcerans (C. ulcerans) may cause diphtheria in humans and can be carried by a wide range of animal species including dairy cows and, more recently, dogs and cats that have been increasingly involved in zoonotic trasmission. We isolated and characterized, by WGS, a toxigenic C. ulcerans strain from a diseased horse in the United Kingdom showing clinical signs of respiratory diphtheria comparable to those seen in people. Our results indicate a role for horses as reservoirs for zoonotic C. ulcerans.

Original language	English
Article number	650238
Journal	Frontiers in Veterinary Science
Volume	8
DOIs	https://doi.org/10.3389/fvets.2021.650238
Publication status	Published - 1 Jun 2021

Bibliographical note

Funding Information: Genome sequencing was provided by MicrobesNG (http://www.microbesng.uk), which is supported by the BBSRC (grant number BB/L024209/1). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Publisher Copyright: © 2021 Zendri, Isgren, Sinovich, Richards-Rios, Hopkins, Russell, Groves, Litt, Fry and Timofte.

Citation: Zendri F, Isgren CM, Sinovich M, Richards-Rios P, Hopkins KL, Russell K, Groves N, Litt D, Fry NK and Timofte D (2021) Case Report: Toxigenic Corynebacterium ulcerans Diphtheria-Like Infection in a Horse in the United Kingdom. Front. Vet. Sci. 8:650238.

DOI: 10.3389/fvets.2021.650238

Keywords

ST543
WGS
emerging zoonosis
horse
respiratory diphtheria-like illness
toxigenic Corynebacterium ulcerans

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10.3389/fvets.2021.650238Licence: CC BY

Zendri2021CaseReportToxigenicCorynebacteriumUlceransDiphtheriaFront.Vet.Sci.Final published version, 1.66 MBLicence: CC BY

Cite this

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abstract = "Corynebacterium ulcerans (C. ulcerans) may cause diphtheria in humans and can be carried by a wide range of animal species including dairy cows and, more recently, dogs and cats that have been increasingly involved in zoonotic trasmission. We isolated and characterized, by WGS, a toxigenic C. ulcerans strain from a diseased horse in the United Kingdom showing clinical signs of respiratory diphtheria comparable to those seen in people. Our results indicate a role for horses as reservoirs for zoonotic C. ulcerans.",

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note = "Funding Information: Genome sequencing was provided by MicrobesNG (http://www.microbesng.uk), which is supported by the BBSRC (grant number BB/L024209/1). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Publisher Copyright: {\textcopyright} 2021 Zendri, Isgren, Sinovich, Richards-Rios, Hopkins, Russell, Groves, Litt, Fry and Timofte. Citation: Zendri F, Isgren CM, Sinovich M, Richards-Rios P, Hopkins KL, Russell K, Groves N, Litt D, Fry NK and Timofte D (2021) Case Report: Toxigenic Corynebacterium ulcerans Diphtheria-Like Infection in a Horse in the United Kingdom. Front. Vet. Sci. 8:650238. DOI: 10.3389/fvets.2021.650238",

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Case Report: Toxigenic Corynebacterium ulcerans Diphtheria-Like Infection in a Horse in the United Kingdom

Abstract

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Keywords

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