Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and medium-term outcomes in congenital heart disease

Kuberan Pushparajah, Aphrodite Tzifa, Aaron Bell, James K. Wong, Tarique Hussain, Israel Valverde, Hannah R. Bellsham-Revell, Gerald Greil, John M. Simpson, Tobias Schaeffter, Reza Razavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Background: Selection of patients with congenital heart disease for surgical septation in biventricular repair or surgical palliation in functionally single ventricles requires low pulmonary vascular resistance (PVR). Where there is uncertainty, PVR can be assessed using hybrid cardiovascular magnetic resonance (CMR) and fluoroscopic (X-Ray) guided cardiac catheterizations (XMR). CMR/XMR catheterization is a validated technique for accurate assessment of pulmonary vascular resistance. However, data concerning its application in clinical practice is lacking. Methods: PVR assessments were performed in 167 studies in 149 congenital heart disease patients by CMR/XMR catheterization. Data was collated on patient demographics, procedural data, complications and outcomes. Institutional ethics approval was obtained. Results: Median age was 3.6 years (6 days - 67 years) and weight 13.8 kg (2.3 -122 kg). One hundred and eight studies were in biventricular circulations and 59 in functionally single ventricles. Median radiation dose was 0.72 mSv. A baseline Qp:Qs ≤2.75 in biventricular circulations with left-to-right shunts predicted a PVR ≥6 WU.m2 with 100% sensitivity and 48% specificity. Median follow up until death or last review was 4.2 years (4 days - 11 years). Eighty-four patients had a surgical or catheter intervention based on CMR/XMR catheterization findings at a median of 94 days after the study. This included successful biventricular repair at resting PVR values ≤6 WU.m2 and Fontan completion at ≤4 WU.m2. Conclusion: PVR measured by CMR/XMR catheterization allows accurate stratification for intervention in patients with congenital heart disease in both, biventricular and univentricular circulations.

Original languageEnglish
Article number28
JournalJournal of Cardiovascular Magnetic Resonance
Issue number1
Publication statusPublished - 14 Apr 2015
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The Division of Imaging Sciences receives support as the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; as well as the BHF Centre of Excellence). The authors would like to thank the staff of the cardiovascular magnetic resonance department at Evelina London Children’s Hospital.

Publisher Copyright:
© 2015 Pushparajah et al.; licensee BioMed Central.


  • Cardiovascular magnetic resonance
  • Catheterization
  • Congenital heart disease
  • Interventional cardiovascular magnetic resonance
  • Pulmonary vascular resistance


Dive into the research topics of 'Cardiovascular Magnetic Resonance catheterization derived pulmonary vascular resistance and medium-term outcomes in congenital heart disease'. Together they form a unique fingerprint.

Cite this