Can plasma HHV8 viral load be used to differentiate multicentric Castleman disease from Kaposi sarcoma?

R. Sayer, J. Paul, P. W. Tuke, S. Hargreaves, M. Noursadeghi, Richard Tedder, P. Grant, S. G. Edwards, R. F. Miller

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We measured plasma human herpesvirus 8 (HHV8) DNA load in consecutive patients presenting with HIV-associated multicentric Castleman disease (MCD) and in contemporaneous patients who had Kaposi sarcoma (KS), lymphoma or other diagnoses. All 11 patients with MCD had detectable plasma HHV8 DNA compared with 18 (72%) of 25 patients with KS, none with lymphoma and one of 38 patients with other diagnoses. Detectable plasma HHV8 DNA levels were higher among MCD patients, median (interquartile range [IQR]) = 43,500 (5200-150,000) copies/mL, when compared with those with KS, median (IQR) = 320 (167-822) copies/mL and those with lymphoma and other diagnoses (one-way analysis of variance; P = 0.0303). Using receiver operating characteristic analysis, a cut-off of >1000 copies HHV8 DNA/mL of plasma helped to discriminate between MCD and other diagnoses, with a specificity of 94.7% and a negative predictive value of 97.3%. The level of HHV8 viraemia, while not diagnostic, may aid discrimination between patients with MCD and those with KS and other systemic illnesses.

Original languageEnglish
Pages (from-to)585-589
Number of pages5
JournalInternational Journal of STD and AIDS
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2011

Bibliographical note

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • AIDS
  • Castleman disease
  • DNA load
  • Fever
  • HHV8
  • HIV
  • Human herpesvirus 8
  • Kaposi sarcoma
  • Lymphoma
  • Multicentric

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