Can animal models predict protection provided by meningococcal vaccines?

Michelle Finney, Denise Halliwell, Andrew Gorringe*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Animal infection models are valuable for the development and assessment of meningococcal vaccines because interactions of the organism with the entire immune system can be assessed. There is no ideal animal disease model that mimics the course of human disease but the two most widely used are intraperitoneal (IP) infection of adult mice or infant rats. Recent developments using transgenic mice expressing human CD46 give hope that improved models will be developed that better predict vaccine efficacy.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalDrug Discovery Today: Disease Models
Issue number1
Publication statusPublished - 2006

Bibliographical note

Funding Information:
• Health Protection Agency, infections • Who Heath Organization, Health topics, meningitis • Meningitis Trust •, a web resource for the Neisseria community • Meningitis Research Foundation


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