Can animal models predict protection provided by meningococcal vaccines?

Michelle Finney; Denise Halliwell; Andrew Gorringe

doi:10.1016/j.ddmod.2006.03.002

Can animal models predict protection provided by meningococcal vaccines?

Michelle Finney, Denise Halliwell, Andrew Gorringe^*

^*Corresponding author for this work

Research & Development Institute Scientific Leaders

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Animal infection models are valuable for the development and assessment of meningococcal vaccines because interactions of the organism with the entire immune system can be assessed. There is no ideal animal disease model that mimics the course of human disease but the two most widely used are intraperitoneal (IP) infection of adult mice or infant rats. Recent developments using transgenic mice expressing human CD46 give hope that improved models will be developed that better predict vaccine efficacy.

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	Drug Discovery Today: Disease Models
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmod.2006.03.002
Publication status	Published - 2006

Bibliographical note

Funding Information:
• Health Protection Agency, infections http://www.hpa.org.uk/infections/topics_az/meningo/menu3.htm • Who Heath Organization, Health topics, meningitis http://www.who.int/topics/meningitis/en/ • Meningitis Trust http://www.meningitis-trust.org/ • Neisseria.org, a web resource for the Neisseria community http://neisseria.org/ • Meningitis Research Foundation http://www.meningitis.org/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ddmod.2006.03.002

Cite this

@article{171f97927a3e4544aad2be374ddb256b,

title = "Can animal models predict protection provided by meningococcal vaccines?",

abstract = "Animal infection models are valuable for the development and assessment of meningococcal vaccines because interactions of the organism with the entire immune system can be assessed. There is no ideal animal disease model that mimics the course of human disease but the two most widely used are intraperitoneal (IP) infection of adult mice or infant rats. Recent developments using transgenic mice expressing human CD46 give hope that improved models will be developed that better predict vaccine efficacy.",

author = "Michelle Finney and Denise Halliwell and Andrew Gorringe",

note = "Funding Information: • Health Protection Agency, infections http://www.hpa.org.uk/infections/topics_az/meningo/menu3.htm • Who Heath Organization, Health topics, meningitis http://www.who.int/topics/meningitis/en/ • Meningitis Trust http://www.meningitis-trust.org/ • Neisseria.org, a web resource for the Neisseria community http://neisseria.org/ • Meningitis Research Foundation http://www.meningitis.org/ ",

year = "2006",

doi = "10.1016/j.ddmod.2006.03.002",

language = "English",

volume = "3",

pages = "77--81",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",