Campylobacter pylori: clinical, histological, and serological studies

C. Musgrove, F. J. Bolton, A. M. Krypczyk, J. M. Temperley, S. A. Cairns, W. G. Owen, D. N. Hutchinson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The presence of Campylobacterpylori, histologically diagnosed gastritis, and antibodies to C pylori were determined in a series of 113 patients undergoing endoscopy. Paired biopsy specimens from the fundus, body, and antrum were collected from 59 patients and from the antrum of 54 patients. The presence of Cpylori was confirmed by either culture or silver stain in 30 of 59, 31 of 59, and 54 of 103 biopsy specimens from the fundus, body, and antrum, respectively. Of the specimens which contained C pylori 20 of 30 (66%) from the fundus, 25 of 31 (80%) from the body, and 54 (100%) from the antrum showed gastritis. Cpylori and gastritis were shown in seven of nine (78 1%) of patients with gastric ulcers and in nine of 11 (82%) of patients with duodenal ulcers. Using an enzyme linked immunosorbent assay (ELISA) technique to detect IgG antibody to C pylori, all patients with histologically diagnosed gastritis and organisms present had titres of ≥ 640; eight of 39 (21 %) ofpatients without gastritis and without organisms gave similar titres. Hence the presence ofC pylori was associated with gastritis and with raised titres of IgG antibody.

Original languageEnglish
Pages (from-to)1316-1321
Number of pages6
JournalJournal of Clinical Pathology
Issue number12
Publication statusPublished - 1988
Externally publishedYes


Dive into the research topics of 'Campylobacter pylori: clinical, histological, and serological studies'. Together they form a unique fingerprint.

Cite this