CABAS: A freely available PC program for fitting calibration curves in chromosome aberration dosimetry

Joanna Deperas; Marta Szłuíska; Marta Deperas-Kaminska; Alan Edwards; David Lloyd; Carita Lindholm; Horst Romm; Laurence Roy; Raymond Moss; Josselin Morand; Andrzej Wojcik

doi:10.1093/rpd/ncm137

CABAS: A freely available PC program for fitting calibration curves in chromosome aberration dosimetry

Joanna Deperas, Marta Szłuíska, Marta Deperas-Kaminska, Alan Edwards, David Lloyd, Carita Lindholm, Horst Romm, Laurence Roy, Raymond Moss, Josselin Morand, Andrzej Wojcik^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure.

Original language	English
Pages (from-to)	115-123
Number of pages	9
Journal	Radiation Protection Dosimetry
Volume	124
Issue number	2
DOIs	https://doi.org/10.1093/rpd/ncm137
Publication status	Published - Apr 2007

Bibliographical note

Funding Information:
Joanna Deperas1,2, Marta Szłuińska3, Marta Deperas-Kaminska2,4, Alan Edwards3, David Lloyd3, Carita Lindholm5, Horst Romm6, Laurence Roy7, Raymond Moss8, Josselin Morand8 and Andrzej Wojcik1,4,8,* 1Department of Radiation Biology and Health Protection, Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warszawa, Poland 2Joint Institute for Nuclear Research, Dubna, Russia 3Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, UK 4Department of Radiation Biology and Immunology, S´więtokrzyska Academy, Kielce, Poland 5STUK – Radiation and Nuclear Safety Authority, Helsinki, Finland 6Institut für Strahlenhygiene, Bundesamt für Strahlenschutz, Neuherberg, Germany 7Département de Protection de la santé de l’Homme, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses Cedex, France 8Institute for Energy – JRC European Commission, Postbus 2, 1755 ZG Petten, Netherlands

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10.1093/rpd/ncm137

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title = "CABAS: A freely available PC program for fitting calibration curves in chromosome aberration dosimetry",

abstract = "The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure.",

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AU - Morand, Josselin

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CABAS: A freely available PC program for fitting calibration curves in chromosome aberration dosimetry

Abstract

Bibliographical note

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