Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches

Viola C. Scoffone, Laurent R. Chiarelli, Gabriele Trespidi, Massimo Mentasti, Giovanna Riccardi, Silvia Buroni*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    113 Citations (Scopus)

    Abstract

    Burkholderia cenocepacia is an opportunistic pathogen particularly dangerous for cystic fibrosis (CF) patients. It can cause a severe decline in CF lung function possibly developing into a life-threatening systemic infection known as cepacia syndrome. Antibiotic resistance and presence of numerous virulence determinants in the genome make B. cenocepacia extremely difficult to treat. Better understanding of its resistance profiles and mechanisms is crucial to improve management of these infections. Here, we present the clinical distribution of B. cenocepacia described in the last 6 years and methods for identification and classification of epidemic strains. We also detail new antibiotics, clinical trials, and alternative approaches reported in the literature in the last 5 years to tackle B. cenocepacia resistance issue. All together these findings point out the urgent need of new and alternative therapies to improve CF patients' life expectancy.

    Original languageEnglish
    Article number1592
    JournalFrontiers in Microbiology
    Volume8
    Issue numberAUG
    DOIs
    Publication statusPublished - 22 Aug 2017

    Bibliographical note

    Publisher Copyright:
    © 2017 Scoffone, Chiarelli, Trespidi, Mentasti, Riccardi and Buroni.

    Keywords

    • Antibiotics
    • Burkholderia cenocepacia
    • Epidemiology
    • New therapies
    • Resistance

    Fingerprint

    Dive into the research topics of 'Burkholderia cenocepacia infections in cystic fibrosis patients: Drug resistance and therapeutic approaches'. Together they form a unique fingerprint.

    Cite this