Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies

Keiko Wada; Koshi Kuboyama; Sarah Krull Abe; Md Shafiur Rahman; Md Rashedul Islam; Eiko Saito; Chisato Nagata; Norie Sawada; Akiko Tamakoshi; Xiao Ou Shu; Ritsu Sakata; Atsushi Hozawa; Seiki Kanemura; Hidemi Ito; Yumi Sugawara; Sue K. Park; Sun Seog Kweon; Ayami Ono; Takashi Kimura; Wanqing Wen; Isao Oze; Min Ho Shin; Aesun Shin; Jeongseon Kim; Jung Eun Lee; Keitaro Matsuo; Nathaniel Rothman; You Lin Qiao; Wei Zheng; Paolo Boffetta; Manami Inoue

doi:10.1186/s13058-024-01907-5

Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies

Keiko Wada^*, Koshi Kuboyama, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Chisato Nagata, Norie Sawada, Akiko Tamakoshi, Xiao Ou Shu, Ritsu Sakata, Atsushi Hozawa, Seiki Kanemura, Hidemi Ito, Yumi Sugawara, Sue K. Park, Sun Seog Kweon, Ayami Ono, Takashi Kimura, Wanqing WenIsao Oze, Min Ho Shin, Aesun Shin, Jeongseon Kim, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You Lin Qiao, Wei Zheng, Paolo Boffetta, Manami Inoue

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women. Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China. Participants’ height and weight were obtained by measurement or self-reports at cohort baseline. Breast cancer was defined as code C50.0-C50.9 according to the International Classification. Using a Cox proportional hazards model, hazard ratios of breast cancer were estimated for each body mass index category, with the reference group set as the group with a body mass index of 21 to < 23 kg/m². The hazard ratio for a 5 kg/m² increase in body mass index was also calculated. Results: During a mean 16.6 years of follow-up, 4819 women developed breast cancer. Similar to Westerners, a steady increase in breast cancer risk with increasing body mass index was observed in postmenopausal women, but the slope of the risk increase appeared to slow at a body mass index of 26–28 kg/m². In premenopausal women, the inverse association seen in Westerners was not observed. The risk of developing breast cancer after 50 years of age increased slightly with increasing body mass index, which was more pronounced in the older birth cohort. There was no significant association between body mass index and the risk of developing breast cancer before 50 years of age, but the risk estimates changed from positive to negative as the birth cohort got younger. Conclusions: In East Asia, the role of body mass index in breast cancer in premenopausal women may be changing along with the increase in obesity and breast cancer. The increased risk of postmenopausal breast cancer with a higher body mass index was as robust as that of Western women.

Original language	English
Article number	158
Journal	Breast Cancer Research
Volume	26
Issue number	1
DOIs	https://doi.org/10.1186/s13058-024-01907-5
Publication status	Published - Dec 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Keywords

Asians
Body mass index
Breast cancer
Pooled analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13058-024-01907-5

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Wada, K., Kuboyama, K., Abe, S. K., Rahman, M. S., Islam, M. R., Saito, E., Nagata, C., Sawada, N., Tamakoshi, A., Shu, X. O., Sakata, R., Hozawa, A., Kanemura, S., Ito, H., Sugawara, Y., Park, S. K., Kweon, S. S., Ono, A., Kimura, T., ... Inoue, M. (2024). Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies. Breast Cancer Research, 26(1), Article 158. https://doi.org/10.1186/s13058-024-01907-5

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title = "Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies",

abstract = "Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women. Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China. Participants{\textquoteright} height and weight were obtained by measurement or self-reports at cohort baseline. Breast cancer was defined as code C50.0-C50.9 according to the International Classification. Using a Cox proportional hazards model, hazard ratios of breast cancer were estimated for each body mass index category, with the reference group set as the group with a body mass index of 21 to < 23 kg/m2. The hazard ratio for a 5 kg/m2 increase in body mass index was also calculated. Results: During a mean 16.6 years of follow-up, 4819 women developed breast cancer. Similar to Westerners, a steady increase in breast cancer risk with increasing body mass index was observed in postmenopausal women, but the slope of the risk increase appeared to slow at a body mass index of 26–28 kg/m2. In premenopausal women, the inverse association seen in Westerners was not observed. The risk of developing breast cancer after 50 years of age increased slightly with increasing body mass index, which was more pronounced in the older birth cohort. There was no significant association between body mass index and the risk of developing breast cancer before 50 years of age, but the risk estimates changed from positive to negative as the birth cohort got younger. Conclusions: In East Asia, the role of body mass index in breast cancer in premenopausal women may be changing along with the increase in obesity and breast cancer. The increased risk of postmenopausal breast cancer with a higher body mass index was as robust as that of Western women.",

keywords = "Asians, Body mass index, Breast cancer, Pooled analysis",

author = "Keiko Wada and Koshi Kuboyama and Abe, \{Sarah Krull\} and Rahman, \{Md Shafiur\} and Islam, \{Md Rashedul\} and Eiko Saito and Chisato Nagata and Norie Sawada and Akiko Tamakoshi and Shu, \{Xiao Ou\} and Ritsu Sakata and Atsushi Hozawa and Seiki Kanemura and Hidemi Ito and Yumi Sugawara and Park, \{Sue K.\} and Kweon, \{Sun Seog\} and Ayami Ono and Takashi Kimura and Wanqing Wen and Isao Oze and Shin, \{Min Ho\} and Aesun Shin and Jeongseon Kim and Lee, \{Jung Eun\} and Keitaro Matsuo and Nathaniel Rothman and Qiao, \{You Lin\} and Wei Zheng and Paolo Boffetta and Manami Inoue",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1186/s13058-024-01907-5",

language = "English",

volume = "26",

journal = "Breast Cancer Research",

issn = "1465-5411",

publisher = "BioMed Central Ltd.",

number = "1",

}

Wada, K, Kuboyama, K, Abe, SK, Rahman, MS, Islam, MR, Saito, E, Nagata, C, Sawada, N, Tamakoshi, A, Shu, XO, Sakata, R, Hozawa, A, Kanemura, S, Ito, H, Sugawara, Y, Park, SK, Kweon, SS, Ono, A, Kimura, T, Wen, W, Oze, I, Shin, MH, Shin, A, Kim, J, Lee, JE, Matsuo, K, Rothman, N, Qiao, YL, Zheng, W, Boffetta, P & Inoue, M 2024, 'Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies', Breast Cancer Research, vol. 26, no. 1, 158. https://doi.org/10.1186/s13058-024-01907-5

TY - JOUR

T1 - Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women

T2 - a pooled analysis of 13 cohort studies

AU - Wada, Keiko

AU - Kuboyama, Koshi

AU - Abe, Sarah Krull

AU - Rahman, Md Shafiur

AU - Islam, Md Rashedul

AU - Saito, Eiko

AU - Nagata, Chisato

AU - Sawada, Norie

AU - Tamakoshi, Akiko

AU - Shu, Xiao Ou

AU - Sakata, Ritsu

AU - Hozawa, Atsushi

AU - Kanemura, Seiki

AU - Ito, Hidemi

AU - Sugawara, Yumi

AU - Park, Sue K.

AU - Kweon, Sun Seog

AU - Ono, Ayami

AU - Kimura, Takashi

AU - Wen, Wanqing

AU - Oze, Isao

AU - Shin, Min Ho

AU - Shin, Aesun

AU - Kim, Jeongseon

AU - Lee, Jung Eun

AU - Matsuo, Keitaro

AU - Rothman, Nathaniel

AU - Qiao, You Lin

AU - Zheng, Wei

AU - Boffetta, Paolo

AU - Inoue, Manami

PY - 2024/12

Y1 - 2024/12

N2 - Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women. Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China. Participants’ height and weight were obtained by measurement or self-reports at cohort baseline. Breast cancer was defined as code C50.0-C50.9 according to the International Classification. Using a Cox proportional hazards model, hazard ratios of breast cancer were estimated for each body mass index category, with the reference group set as the group with a body mass index of 21 to < 23 kg/m2. The hazard ratio for a 5 kg/m2 increase in body mass index was also calculated. Results: During a mean 16.6 years of follow-up, 4819 women developed breast cancer. Similar to Westerners, a steady increase in breast cancer risk with increasing body mass index was observed in postmenopausal women, but the slope of the risk increase appeared to slow at a body mass index of 26–28 kg/m2. In premenopausal women, the inverse association seen in Westerners was not observed. The risk of developing breast cancer after 50 years of age increased slightly with increasing body mass index, which was more pronounced in the older birth cohort. There was no significant association between body mass index and the risk of developing breast cancer before 50 years of age, but the risk estimates changed from positive to negative as the birth cohort got younger. Conclusions: In East Asia, the role of body mass index in breast cancer in premenopausal women may be changing along with the increase in obesity and breast cancer. The increased risk of postmenopausal breast cancer with a higher body mass index was as robust as that of Western women.

AB - Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women. Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China. Participants’ height and weight were obtained by measurement or self-reports at cohort baseline. Breast cancer was defined as code C50.0-C50.9 according to the International Classification. Using a Cox proportional hazards model, hazard ratios of breast cancer were estimated for each body mass index category, with the reference group set as the group with a body mass index of 21 to < 23 kg/m2. The hazard ratio for a 5 kg/m2 increase in body mass index was also calculated. Results: During a mean 16.6 years of follow-up, 4819 women developed breast cancer. Similar to Westerners, a steady increase in breast cancer risk with increasing body mass index was observed in postmenopausal women, but the slope of the risk increase appeared to slow at a body mass index of 26–28 kg/m2. In premenopausal women, the inverse association seen in Westerners was not observed. The risk of developing breast cancer after 50 years of age increased slightly with increasing body mass index, which was more pronounced in the older birth cohort. There was no significant association between body mass index and the risk of developing breast cancer before 50 years of age, but the risk estimates changed from positive to negative as the birth cohort got younger. Conclusions: In East Asia, the role of body mass index in breast cancer in premenopausal women may be changing along with the increase in obesity and breast cancer. The increased risk of postmenopausal breast cancer with a higher body mass index was as robust as that of Western women.

KW - Asians

KW - Body mass index

KW - Breast cancer

KW - Pooled analysis

UR - https://www.scopus.com/pages/publications/85209117011

U2 - 10.1186/s13058-024-01907-5

DO - 10.1186/s13058-024-01907-5

M3 - Article

C2 - 39543702

AN - SCOPUS:85209117011

SN - 1465-5411

VL - 26

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 1

M1 - 158

ER -

Body mass index and breast cancer risk in premenopausal and postmenopausal East Asian women: a pooled analysis of 13 cohort studies

Abstract

Bibliographical note

Keywords

UN SDGs

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