Biosafety standards for working with crimean-congo hemorrhagic fever virus

Manfred Weidmann; Tatjana Avsic-Zupanc; Silvia Bino; Michelle Bouloy; Felicity Burt; Sadegh Chinikar; Iva Christova; Isuf Dedushaj; Ahmed El-Sanousi; Nazif Elaldi; Roger Hewson; Frank T. Hufert; Isme Humolli; Petrus Jansen Van Vuren; Zeliha Koçak Tufan; Gülay Korukluoglu; Pieter Lyssen; Ali Mirazimi; Johan Neyts; Matthias Niedrig; Aykut Ozkul; Anna Papa; Janusz Paweska; Amadou A. Sall; Connie S. Schmaljohn; Robert Swanepoel; Yavuz Uyar; Friedemann Weber; Herve Zeller

doi:10.1099/jgv.0.000610

Biosafety standards for working with crimean-congo hemorrhagic fever virus

Manfred Weidmann^*, Tatjana Avsic-Zupanc, Silvia Bino, Michelle Bouloy, Felicity Burt, Sadegh Chinikar, Iva Christova, Isuf Dedushaj, Ahmed El-Sanousi, Nazif Elaldi, Roger Hewson, Frank T. Hufert, Isme Humolli, Petrus Jansen Van Vuren, Zeliha Koçak Tufan, Gülay Korukluoglu, Pieter Lyssen, Ali Mirazimi, Johan Neyts, Matthias NiedrigAykut Ozkul, Anna Papa, Janusz Paweska, Amadou A. Sall, Connie S. Schmaljohn, Robert Swanepoel, Yavuz Uyar, Friedemann Weber, Herve Zeller

^*Corresponding author for this work

Research & Development Institute Scientific Leaders

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.

Original language	English
Article number	000610
Pages (from-to)	2799-2808
Number of pages	10
Journal	Journal of General Virology
Volume	97
Issue number	11
DOIs	https://doi.org/10.1099/jgv.0.000610
Publication status	Published - Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 The Authors.

Keywords

Aerosol
Biosafety
Crimean-Congo haemorrhagic fever virus
Droplet
Laboratory acquired infection
Nosocomial infection
Personal protective equipment
Seroepidemiology

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10.1099/jgv.0.000610

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Weidmann, M., Avsic-Zupanc, T., Bino, S., Bouloy, M., Burt, F., Chinikar, S., Christova, I., Dedushaj, I., El-Sanousi, A., Elaldi, N., Hewson, R., Hufert, F. T., Humolli, I., Van Vuren, P. J., Tufan, Z. K., Korukluoglu, G., Lyssen, P., Mirazimi, A., Neyts, J., ... Zeller, H. (2016). Biosafety standards for working with crimean-congo hemorrhagic fever virus. Journal of General Virology, 97(11), 2799-2808. Article 000610. https://doi.org/10.1099/jgv.0.000610

@article{80088f96281a44579292182261b528b3,

title = "Biosafety standards for working with crimean-congo hemorrhagic fever virus",

abstract = "In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.",

keywords = "Aerosol, Biosafety, Crimean-Congo haemorrhagic fever virus, Droplet, Laboratory acquired infection, Nosocomial infection, Personal protective equipment, Seroepidemiology",

author = "Manfred Weidmann and Tatjana Avsic-Zupanc and Silvia Bino and Michelle Bouloy and Felicity Burt and Sadegh Chinikar and Iva Christova and Isuf Dedushaj and Ahmed El-Sanousi and Nazif Elaldi and Roger Hewson and Hufert, {Frank T.} and Isme Humolli and {Van Vuren}, {Petrus Jansen} and Tufan, {Zeliha Ko{\c c}ak} and G{\"u}lay Korukluoglu and Pieter Lyssen and Ali Mirazimi and Johan Neyts and Matthias Niedrig and Aykut Ozkul and Anna Papa and Janusz Paweska and Sall, {Amadou A.} and Schmaljohn, {Connie S.} and Robert Swanepoel and Yavuz Uyar and Friedemann Weber and Herve Zeller",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors.",

year = "2016",

month = nov,

doi = "10.1099/jgv.0.000610",

language = "English",

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Weidmann, M, Avsic-Zupanc, T, Bino, S, Bouloy, M, Burt, F, Chinikar, S, Christova, I, Dedushaj, I, El-Sanousi, A, Elaldi, N, Hewson, R, Hufert, FT, Humolli, I, Van Vuren, PJ, Tufan, ZK, Korukluoglu, G, Lyssen, P, Mirazimi, A, Neyts, J, Niedrig, M, Ozkul, A, Papa, A, Paweska, J, Sall, AA, Schmaljohn, CS, Swanepoel, R, Uyar, Y, Weber, F & Zeller, H 2016, 'Biosafety standards for working with crimean-congo hemorrhagic fever virus', Journal of General Virology, vol. 97, no. 11, 000610, pp. 2799-2808. https://doi.org/10.1099/jgv.0.000610

TY - JOUR

T1 - Biosafety standards for working with crimean-congo hemorrhagic fever virus

AU - Weidmann, Manfred

AU - Avsic-Zupanc, Tatjana

AU - Bino, Silvia

AU - Bouloy, Michelle

AU - Burt, Felicity

AU - Chinikar, Sadegh

AU - Christova, Iva

AU - Dedushaj, Isuf

AU - El-Sanousi, Ahmed

AU - Elaldi, Nazif

AU - Hewson, Roger

AU - Hufert, Frank T.

AU - Humolli, Isme

AU - Van Vuren, Petrus Jansen

AU - Tufan, Zeliha Koçak

AU - Korukluoglu, Gülay

AU - Lyssen, Pieter

AU - Mirazimi, Ali

AU - Neyts, Johan

AU - Niedrig, Matthias

AU - Ozkul, Aykut

AU - Papa, Anna

AU - Paweska, Janusz

AU - Sall, Amadou A.

AU - Schmaljohn, Connie S.

AU - Swanepoel, Robert

AU - Uyar, Yavuz

AU - Weber, Friedemann

AU - Zeller, Herve

PY - 2016/11

Y1 - 2016/11

N2 - In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.

AB - In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.

KW - Aerosol

KW - Biosafety

KW - Crimean-Congo haemorrhagic fever virus

KW - Droplet

KW - Laboratory acquired infection

KW - Nosocomial infection

KW - Personal protective equipment

KW - Seroepidemiology

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U2 - 10.1099/jgv.0.000610

DO - 10.1099/jgv.0.000610

M3 - Review article

C2 - 27667586

AN - SCOPUS:84995639445

SN - 0022-1317

VL - 97

SP - 2799

EP - 2808

JO - Journal of General Virology

JF - Journal of General Virology

IS - 11

M1 - 000610

ER -

Biosafety standards for working with crimean-congo hemorrhagic fever virus

Abstract

Bibliographical note

Keywords

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