Biomarkers of treatment success in fully sensitive pulmonary tuberculosis patients: A multicenter longitudinal study

Vladyslav Nikolayevskyy, Yanina Balabanova, Irina Kontsevaya, Olga Ignatyeva, Girts Skenders, Edita Vasiliauskiene, David Van Bockel, Francis Drobniewski*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Aim: Novel biomarkers that are able to accurately monitor tuberculosis (TB) treatment effectiveness are needed to adjust therapy and identify a need for a regimen change. Materials methods: In our study, conducted on a cohort comprising 100 pulmonary TB patients, we analyzed the role of plasma cytokines and Toll-like receptors expression as biomarkers of treatment response. Results: Changes in toll-interacting protein (TOLLIP) and lymphocyte antigen 96 (LY96) gene expression as well as nine cytokine levels over the first 2 months were significantly associated with successful treatment outcome. Successful treatment was associated with higher serum concentration of Toll-like receptor-2. Conclusion: Our results suggest that differential expression of specific effector molecules and dynamics of selected cytokines may help to identify those responding to TB treatment early.

    Original languageEnglish
    Pages (from-to)1439-1452
    Number of pages14
    JournalBiomarkers in Medicine
    Volume14
    Issue number15
    DOIs
    Publication statusPublished - Oct 2020

    Bibliographical note

    Funding Information:
    This study has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement number FP7-223681 (TB PANNET). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

    Keywords

    • Toll-like receptors
    • biomarkers
    • cytokines
    • treatment response
    • tuberculosis

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