Biomarkers and omics of health effects associated with traffic-related air pollution

Christiana Demetriou, Paolo Vineis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Environmental causes feature among the top global health risks, and several prospective studies demonstrate generally consistent results, indicating that long-term exposure to air pollution is associated with lung cancer incidence and mortality. Biomarkers can enhance research on the health effects of air pollution by improving exposure assessment, increasing the understanding of mechanisms, and enabling the investigation of individual susceptibility. The development of high-resolution and high-throughput technologies interrogating -omics has yielded an unprecedented perspective in air pollution science and it can be used to interrogate the exposome, which comprises biologically active chemicals in response to external environmental stimuli and the internal chemical environment. Thus, the exposome approach to air pollution looks like a promising avenue to make sense of the multitude of signals emerging from -omic investigations and to strengthen causal inferences on the health effects of air pollution.

Original languageEnglish
Title of host publicationTraffic-Related Air Pollution
PublisherElsevier
Pages281-309
Number of pages29
ISBN (Electronic)9780128181225
DOIs
Publication statusPublished - 1 Jan 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • -omics
  • Biomarkers
  • Exposome
  • Exposome-wide association studies
  • Hallmarks of disease
  • Key characteristics of carcinogens
  • Lung cancer
  • Traffic-related air pollution

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