Environmental causes feature among the top global health risks, and several prospective studies demonstrate generally consistent results, indicating that long-term exposure to air pollution is associated with lung cancer incidence and mortality. Biomarkers can enhance research on the health effects of air pollution by improving exposure assessment, increasing the understanding of mechanisms, and enabling the investigation of individual susceptibility. The development of high-resolution and high-throughput technologies interrogating -omics has yielded an unprecedented perspective in air pollution science and it can be used to interrogate the exposome, which comprises biologically active chemicals in response to external environmental stimuli and the internal chemical environment. Thus, the exposome approach to air pollution looks like a promising avenue to make sense of the multitude of signals emerging from -omic investigations and to strengthen causal inferences on the health effects of air pollution.
|Title of host publication||Traffic-Related Air Pollution|
|Number of pages||29|
|Publication status||Published - 1 Jan 2020|
Bibliographical notePublisher Copyright:
© 2020 Elsevier Inc.
- Exposome-wide association studies
- Hallmarks of disease
- Key characteristics of carcinogens
- Lung cancer
- Traffic-related air pollution