Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Joanna Bacon, Simon J. Waddell, Mario Alberto Flores-Valdez*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.

Original languageEnglish
Article number102153
JournalTuberculosis
Volume132
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

Funding Information:
The authors are members of the CombiT [3]aB ?Combination Therapy to Tackle TB associated Biofilms? consortium.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • Biofilms
  • Extracellular communities
  • Mycobacterium
  • Pulmonary pathogenesis
  • Tuberculosis

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