Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Joanna Bacon; Simon J. Waddell; Mario Alberto Flores-Valdez

doi:10.1016/j.tube.2021.102153

Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Joanna Bacon, Simon J. Waddell, Mario Alberto Flores-Valdez^*

^*Corresponding author for this work

Research & Technical Staff

Research output: Contribution to journal › Comment/debate

2 Citations (Scopus)

Abstract

Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.

Original language	English
Article number	102153
Journal	Tuberculosis
Volume	132
DOIs	https://doi.org/10.1016/j.tube.2021.102153
Publication status	Published - Jan 2022

Bibliographical note

Funding Information:
The authors are members of the CombiT [3]aB ‘Combination Therapy to Tackle TB associated Biofilms’ consortium.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

Biofilms
Extracellular communities
Mycobacterium
Pulmonary pathogenesis
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2021.102153

Cite this

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title = "Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?",

abstract = "Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.",

keywords = "Biofilms, Extracellular communities, Mycobacterium, Pulmonary pathogenesis, Tuberculosis",

author = "Joanna Bacon and Waddell, {Simon J.} and Flores-Valdez, {Mario Alberto}",

note = "Funding Information: The authors are members of the CombiT [3]aB {\textquoteleft}Combination Therapy to Tackle TB associated Biofilms{\textquoteright} consortium. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = jan,

doi = "10.1016/j.tube.2021.102153",

language = "English",

volume = "132",

journal = "Tuberculosis",

issn = "1472-9792",

publisher = "Elsevier",

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TY - JOUR

T1 - Biofilms in tuberculosis

T2 - What have we learnt in the past decade and what is still unexplored?

AU - Bacon, Joanna

AU - Waddell, Simon J.

AU - Flores-Valdez, Mario Alberto

PY - 2022/1

Y1 - 2022/1

N2 - Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.

AB - Elucidating how Mycobacterium tuberculosis produces biofilms, and its impact for tuberculosis (TB) pathogenesis is gaining momentum. Here, we discuss recent findings reported over the last decade, which help us gain insights into the association between biofilm formation and TB pathogenesis. A new appreciation of extracellular TB phenotypes found in lung lesions will drive drug and vaccine discovery forward to new possibilities.

KW - Biofilms

KW - Extracellular communities

KW - Mycobacterium

KW - Pulmonary pathogenesis

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85119901365&partnerID=8YFLogxK

U2 - 10.1016/j.tube.2021.102153

DO - 10.1016/j.tube.2021.102153

M3 - Comment/debate

AN - SCOPUS:85119901365

SN - 1472-9792

VL - 132

JO - Tuberculosis

JF - Tuberculosis

M1 - 102153

ER -

Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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