Cerebrospinal fluid (CSF) cryptococcal colony-forming unit counts and CSF cryptococcal antigen titers serve as alternative measures of organism load in cryptococcal meningitis. For these measures, we correlated baseline values and rates of decline during the first 2 weeks of therapy in 68 human immunodeficiency virus-seropositive patients with cryptococcal meningitis. At baseline, there was a strong correlation between CSF cryptococcal colony-forming unit counts and CSF cryptococcal antigen titers. During the first 2 weeks of therapy, CSF cryptococcal colony-forming unit counts decreased by >5 logs, and CSF cryptococcal antigen titers decreased by 1.5 dilutions. In individual patients, there was no correlation between the rate of decline in CSF cryptococcal colony-forming unit counts and that in CSF cryptococcal antigen titers.
|Number of pages||4|
|Journal||Journal of Infectious Diseases|
|Publication status||Published - 15 Aug 2005|
Bibliographical noteFunding Information:
Financial support: Lancet International Fellowship (to A.E.B.); Wellcome Trust Training Fellowship (to A.E.B.); Netherlands Foundation for the Advancement of Tropical Research (WOTRO) (to A.E.B.); Wellcome Trust Advanced Training Fellowship (to T.S.H.); St. George’s Hospital Trustees; Wellcome Trust of Great Britain (support to Wellcome Trust–Mahidol University–Oxford Tropical Medicine Research Programme).