Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics

Tom C. Darton; Malcolm Guiver; Simone Naylor; Edward Kaczmarski; Raymond Borrow; Robert C. Read

doi:10.1093/cid/cir433

Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics

Tom C. Darton, Malcolm Guiver, Simone Naylor, Edward Kaczmarski, Raymond Borrow, Robert C. Read^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.

Original language	English
Pages (from-to)	463-467
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	53
Issue number	5
DOIs	https://doi.org/10.1093/cid/cir433
Publication status	Published - 1 Sept 2011

Bibliographical note

Funding Information:
Potential conflicts of interest. R. C. R. is a stockholder in Interleukin Genetics Inc. and has received grant support through his institution from Novartis, Wellcome Trust, and Meningitis charities. All other authors report no potential conflicts.

Funding Information:
Financial support. This work was supported by the Meningitis Research Foundation, Thornbury, Bristol, United Kingdom (award 4/00).

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10.1093/cid/cir433

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title = "Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics",

abstract = "Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.",

author = "Darton, {Tom C.} and Malcolm Guiver and Simone Naylor and Edward Kaczmarski and Raymond Borrow and Read, {Robert C.}",

note = "Funding Information: Potential conflicts of interest. R. C. R. is a stockholder in Interleukin Genetics Inc. and has received grant support through his institution from Novartis, Wellcome Trust, and Meningitis charities. All other authors report no potential conflicts. Funding Information: Financial support. This work was supported by the Meningitis Research Foundation, Thornbury, Bristol, United Kingdom (award 4/00).",

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doi = "10.1093/cid/cir433",

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T1 - Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics

AU - Darton, Tom C.

AU - Guiver, Malcolm

AU - Naylor, Simone

AU - Kaczmarski, Edward

AU - Borrow, Raymond

AU - Read, Robert C.

N1 - Funding Information: Potential conflicts of interest. R. C. R. is a stockholder in Interleukin Genetics Inc. and has received grant support through his institution from Novartis, Wellcome Trust, and Meningitis charities. All other authors report no potential conflicts. Funding Information: Financial support. This work was supported by the Meningitis Research Foundation, Thornbury, Bristol, United Kingdom (award 4/00).

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Y1 - 2011/9/1

N2 - Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.

AB - Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.

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SN - 1058-4838

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JO - Clinical Infectious Diseases

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ER -

Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics

Abstract

Bibliographical note

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