Associations of circulating and dietary vitamin D with prostate cancer risk: A systematic review and dose-response meta-analysis

Rebecca Gilbert; Richard M. Martin; Rebecca Beynon; Ross Harris; Jelena Savovic; Luisa Zuccolo; Geertruida E. Bekkering; William D. Fraser; Jonathan A.C. Sterne; Chris Metcalfe

doi:10.1007/s10552-010-9706-3

Associations of circulating and dietary vitamin D with prostate cancer risk: A systematic review and dose-response meta-analysis

Rebecca Gilbert^*, Richard M. Martin, Rebecca Beynon, Ross Harris, Jelena Savovic, Luisa Zuccolo, Geertruida E. Bekkering, William D. Fraser, Jonathan A.C. Sterne, Chris Metcalfe

^*Corresponding author for this work

Statistics Unit

Research output: Contribution to journal › Article › peer-review

127 Citations (Scopus)

Abstract

Objective We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)2D) concentrations) with prostate cancer. Methods We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response randomeffects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I² statistic quantified between-study variation due to heterogeneity. Results Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I ² = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I² = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I² = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I² = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I² = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)2D was 1.00 (7 studies; 0.87, 1.14; I ² = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I² = 0%) for aggressive prostate cancer. Conclusion Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.

Original language	English
Pages (from-to)	319-340
Number of pages	22
Journal	Cancer Causes and Control
Volume	22
Issue number	3
DOIs	https://doi.org/10.1007/s10552-010-9706-3
Publication status	Published - Mar 2011

Bibliographical note

Funding Information:
Acknowledgments We would like to thank Margaret Burke, dedicated information specialist, for carrying out the systematic literature review in the electronic databases. This work was supported by Cancer Research UK (C31211/A10095 to RG, RMM, CM, WDF) and the World Cancer Research Fund (2006/15 to RMM, CM and WDF). The original Expert Report was funded by the World Cancer Research Fund (Davey Smith, G., Sterne, J.A.C., Bain, C. Burke, M., Donovan, J., Ebrahim, S., Egger, M., Emmett, P., Gunnell, D., Hooper, L., Ness, A. and Oliver, S. Systematic review of associations between diet, nutrition, physical activity and bladder, prostate and kidney cancer. World Cancer Research Fund. 1 September 2003–30 June 2006.).

Keywords

Epidemiology
Meta-analysis
Prostatic neoplasms
Review
Vitamin D

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10552-010-9706-3

Cite this

@article{672f978cc73749de9d18485e079d63a7,

title = "Associations of circulating and dietary vitamin D with prostate cancer risk: A systematic review and dose-response meta-analysis",

abstract = "Objective We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)2D) concentrations) with prostate cancer. Methods We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response randomeffects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I2 statistic quantified between-study variation due to heterogeneity. Results Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I 2 = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I2 = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I2 = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I2 = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I2 = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)2D was 1.00 (7 studies; 0.87, 1.14; I 2 = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I2 = 0%) for aggressive prostate cancer. Conclusion Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.",

keywords = "Epidemiology, Meta-analysis, Prostatic neoplasms, Review, Vitamin D",

author = "Rebecca Gilbert and Martin, {Richard M.} and Rebecca Beynon and Ross Harris and Jelena Savovic and Luisa Zuccolo and Bekkering, {Geertruida E.} and Fraser, {William D.} and Sterne, {Jonathan A.C.} and Chris Metcalfe",

note = "Funding Information: Acknowledgments We would like to thank Margaret Burke, dedicated information specialist, for carrying out the systematic literature review in the electronic databases. This work was supported by Cancer Research UK (C31211/A10095 to RG, RMM, CM, WDF) and the World Cancer Research Fund (2006/15 to RMM, CM and WDF). The original Expert Report was funded by the World Cancer Research Fund (Davey Smith, G., Sterne, J.A.C., Bain, C. Burke, M., Donovan, J., Ebrahim, S., Egger, M., Emmett, P., Gunnell, D., Hooper, L., Ness, A. and Oliver, S. Systematic review of associations between diet, nutrition, physical activity and bladder, prostate and kidney cancer. World Cancer Research Fund. 1 September 2003–30 June 2006.).",

year = "2011",

month = mar,

doi = "10.1007/s10552-010-9706-3",

language = "English",

volume = "22",

pages = "319--340",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

}

TY - JOUR

T1 - Associations of circulating and dietary vitamin D with prostate cancer risk

T2 - A systematic review and dose-response meta-analysis

AU - Gilbert, Rebecca

AU - Martin, Richard M.

AU - Beynon, Rebecca

AU - Harris, Ross

AU - Savovic, Jelena

AU - Zuccolo, Luisa

AU - Bekkering, Geertruida E.

AU - Fraser, William D.

AU - Sterne, Jonathan A.C.

AU - Metcalfe, Chris

N1 - Funding Information: Acknowledgments We would like to thank Margaret Burke, dedicated information specialist, for carrying out the systematic literature review in the electronic databases. This work was supported by Cancer Research UK (C31211/A10095 to RG, RMM, CM, WDF) and the World Cancer Research Fund (2006/15 to RMM, CM and WDF). The original Expert Report was funded by the World Cancer Research Fund (Davey Smith, G., Sterne, J.A.C., Bain, C. Burke, M., Donovan, J., Ebrahim, S., Egger, M., Emmett, P., Gunnell, D., Hooper, L., Ness, A. and Oliver, S. Systematic review of associations between diet, nutrition, physical activity and bladder, prostate and kidney cancer. World Cancer Research Fund. 1 September 2003–30 June 2006.).

PY - 2011/3

Y1 - 2011/3

N2 - Objective We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)2D) concentrations) with prostate cancer. Methods We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response randomeffects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I2 statistic quantified between-study variation due to heterogeneity. Results Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I 2 = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I2 = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I2 = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I2 = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I2 = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)2D was 1.00 (7 studies; 0.87, 1.14; I 2 = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I2 = 0%) for aggressive prostate cancer. Conclusion Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.

AB - Objective We systematically reviewed and meta-analyzed literature examining associations of vitamin D (dietary intake, circulating 25-hydroxy-vitamin-D (25(OH)D), and 1,25-dihydroxy-vitamin-D (1,25(OH)2D) concentrations) with prostate cancer. Methods We searched over 24,000 papers from seven electronic databases (to October 2010) for exposures related to vitamin D. We conducted dose-response randomeffects meta-analyses pooling the log odds ratio (OR) and 95% confidence intervals (CI) per change in natural units of each exposure. The I2 statistic quantified between-study variation due to heterogeneity. Results Twenty-five papers were included. In prospective studies, the OR per 1,000 IU increase in dietary intake was 1.14 (6 studies; CI: 0.99, 1.31; I 2 = 0%) for total prostate cancer and 0.93 (3 studies; 0.63, 1.39; I2 = 25%) for aggressive prostate cancer. Five case-control studies examined dietary intake, but there was a high degree of inconsistency between studies (I2 = 49%). The OR per 10 ng/mL increase in 25(OH)D was 1.04 (14 studies; 0.99, 1.10; I2 = 0%) for total prostate cancer and 0.98 (6 studies; 0.84, 1.15; I2 = 32%) for aggressive prostate cancer. The OR per 10 pg/mL increase in 1,25(OH)2D was 1.00 (7 studies; 0.87, 1.14; I 2 = 41%) for total prostate cancer and 0.86 (2 studies; 0.72, 1.02; I2 = 0%) for aggressive prostate cancer. Conclusion Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.

KW - Epidemiology

KW - Meta-analysis

KW - Prostatic neoplasms

KW - Review

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=79955755462&partnerID=8YFLogxK

U2 - 10.1007/s10552-010-9706-3

DO - 10.1007/s10552-010-9706-3

M3 - Article

C2 - 21203822

AN - SCOPUS:79955755462

SN - 0957-5243

VL - 22

SP - 319

EP - 340

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 3

ER -

Associations of circulating and dietary vitamin D with prostate cancer risk: A systematic review and dose-response meta-analysis

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this