Association of a lukM-positive clone of Staphylococcus aureus with fatal exudative dermatitis in red squirrels (Sciurus vulgaris)

V. R. Simpson*, N. J. Davison, Angela Kearns, Bruno Pichon, L. O. Hudson, M. Koylass, T. Blackett, H. Butler, J. P. Rasigade, A. M. Whatmore

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Fatal exudative dermatitis (FED) is a recently described condition affecting red squirrels (Sciurus vulgaris) on the Isle of Wight and Jersey (Simpson et al., 2010a). Staphylococcus aureus strains isolated from skin lesions in cases of FED were characterised by molecular and phenotypic approaches. The strains were found to belong to a single MLST clonal complex (CC49) representing either ST49 or a novel single locus variant thereof (ST1957), were closely related by other molecular typing approaches, and all possessed the leukotoxin M encoding gene (lukM). In contrast S. aureus was either not isolated from none-FED cases or belonged to distinct and diverse molecular types that, with one exception, did not encode lukM. All isolates from FED cases were susceptible to all antimicrobials tested, including penicillin, and all proved negative for mecA and mecC as well as 14 other staphylococcal toxin genes. As all squirrels affected by FED were infected with S. aureus of the same lineage and encoded the lukM gene, it is possible that strains of this lineage may be involved in the pathogenesis of the dermatitis.

    Original languageEnglish
    Pages (from-to)987-991
    Number of pages5
    JournalVeterinary Microbiology
    Volume162
    Issue number2-4
    DOIs
    Publication statusPublished - 23 Mar 2013

    Bibliographical note

    Funding Information:
    Work carried out at AHVLA Weybridge was supported by an AHVLA Research and Development Internal Investment Fund Project ( RD0016 ) and at AHVLA Polwhele by the AHVLA Diseases of Wildlife Scheme (AHVLA DoWS) . The study on Jersey was funded from several sources including JSPCA Animals’ Shelter , Jersey Ecology Trust Fund , Channel Island Co-operative Society and Moore Stephens . Work performed at Imperial College London was funded by a grant ( BB/D52637X/1 ) from Biotechnology and Biological Sciences Research Council .

    Keywords

    • Dermatitis
    • LukM gene
    • Sciurus vulgaris
    • Staphylococcus aureus CC49

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