Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa

David J. Waine; David Honeybourne; E. Grace Smith; Joanna L. Whitehouse; Chris G. Dowson

doi:10.1128/JCM.00357-08

Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa

David J. Waine, David Honeybourne, E. Grace Smith, Joanna L. Whitehouse, Chris G. Dowson

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.

Original language	English
Pages (from-to)	3491-3493
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	46
Issue number	10
DOIs	https://doi.org/10.1128/JCM.00357-08
Publication status	Published - Oct 2008
Externally published	Yes

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title = "Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa",

abstract = "The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.",

author = "Waine, {David J.} and David Honeybourne and Smith, {E. Grace} and Whitehouse, {Joanna L.} and Dowson, {Chris G.}",

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AU - Waine, David J.

AU - Honeybourne, David

AU - Smith, E. Grace

AU - Whitehouse, Joanna L.

AU - Dowson, Chris G.

PY - 2008/10

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AB - The presence of hypermutator Pseudomonas aeruginosa was associated with poorer lung function in patients at the Adult West Midlands CF Unit. Mucoid isolates were more likely to be hypermutators. The presence of resistant mutant subpopulations was associated with hypermutator phenotype but was not good enough to be used as a test for this phenotype.

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U2 - 10.1128/JCM.00357-08

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AN - SCOPUS:53649108809

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Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa

Abstract

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