Assessment of Effectiveness of Seasonal Influenza Vaccination During Pregnancy in Preventing Influenza Infection in Infants in England, 2013-2014 and 2014-2015

Jemma L. Walker, Hongxin Zhao, Gavin Dabrera, Nicholas Andrews, Sarah L. Thomas, Camille Tsang, Joanna Ellis, Matthew Donati, Richard Pebody

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Maternal influenza vaccination is increasingly recognized to protect infants from influenza infection in their first 6 months. We used the screening method to estimate vaccine effectiveness (VE) against laboratory-confirmed influenza in infants in England, using newly available uptake data from the Clinical Practice Research Datalink pregnancy register, matched on week of birth and region and adjusted for ethnicity. We found VE of 66% (95% confidence interval [CI], 18%-84%) in the 2013-2014 season and 50% (95% CI, 11%-72%) in 2014-2015, with similar VE against influenza-related hospitalization. VE against the dominant circulating influenza strain was higher, at 78% (95% CI, 16%-94%) against H1N1 in 2013-2014, and 60% (95% CI, 16%-81%) against H3N2 in 2014-2015.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalJournal of Infectious Diseases
Volume221
Issue number1
DOIs
Publication statusPublished - 9 Nov 2019

Bibliographical note

Funding Information: This research was funded in part by the NIHR Health Protection Research Unit (HPRU) in Immunisation at the London School of Hygiene and Tropical Medicine in partnership with PHE.

Open Access: Free to read, but no Open Access licence.

Publisher copyright: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Citation: Jemma L Walker, Hongxin Zhao, Gavin Dabrera, Nick Andrews, Sarah L Thomas, Camille Tsang, Joanna Ellis, Matthew Donati, Richard G Pebody, Assessment of Effectiveness of Seasonal Influenza Vaccination During Pregnancy in Preventing Influenza Infection in Infants in England, 2013–2014 and 2014–2015, The Journal of Infectious Diseases, Volume 221, Issue 1, 1 January 2020, Pages 16–20.

DOI: https://doi.org/10.1093/infdis/jiz310

Keywords

  • electronic health records
  • infants
  • influenza
  • pregnancy
  • vaccine effectiveness

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