Assessing cancer risks of low-dose radiation

Leon Mullenders; Mike Atkinson; Herwig Paretzke; Laure Sabatier; Simon Bouffler

doi:10.1038/nrc2677

Assessing cancer risks of low-dose radiation

Leon Mullenders^*
, Mike Atkinson
, Herwig Paretzke
, Laure Sabatier
, Simon Bouffler

^*Corresponding author for this work

Radiation Effects

Research output: Contribution to journal › Review article › peer-review

203 Citations (Scopus)

Abstract

Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

Original language	English
Pages (from-to)	596-604
Number of pages	9
Journal	Nature Reviews Cancer
Volume	9
Issue number	8
DOIs	https://doi.org/10.1038/nrc2677
Publication status	Published - Aug 2009

Bibliographical note

Funding Information:
We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nrc2677

Cite this

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title = "Assessing cancer risks of low-dose radiation",

abstract = "Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.",

author = "Leon Mullenders and Mike Atkinson and Herwig Paretzke and Laure Sabatier and Simon Bouffler",

note = "Funding Information: We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.",

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AU - Mullenders, Leon

AU - Atkinson, Mike

AU - Paretzke, Herwig

AU - Sabatier, Laure

AU - Bouffler, Simon

N1 - Funding Information: We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.

PY - 2009/8

Y1 - 2009/8

N2 - Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

AB - Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

UR - https://www.scopus.com/pages/publications/67749103618

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M3 - Review article

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SP - 596

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JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 8

ER -

Assessing cancer risks of low-dose radiation

Abstract

Bibliographical note

UN SDGs

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