Assessing cancer risks of low-dose radiation

Leon Mullenders; Mike Atkinson; Herwig Paretzke; Laure Sabatier; Simon Bouffler

doi:10.1038/nrc2677

Assessing cancer risks of low-dose radiation

Leon Mullenders^*, Mike Atkinson, Herwig Paretzke, Laure Sabatier, Simon Bouffler

^*Corresponding author for this work

Radiation Effects

Research output: Contribution to journal › Review article › peer-review

187 Citations (Scopus)

Abstract

Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

Original language	English
Pages (from-to)	596-604
Number of pages	9
Journal	Nature Reviews Cancer
Volume	9
Issue number	8
DOIs	https://doi.org/10.1038/nrc2677
Publication status	Published - Aug 2009

Bibliographical note

Funding Information:
We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrc2677

Cite this

@article{75782aaa23634cbebc4e574800971ffb,

title = "Assessing cancer risks of low-dose radiation",

abstract = "Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.",

author = "Leon Mullenders and Mike Atkinson and Herwig Paretzke and Laure Sabatier and Simon Bouffler",

note = "Funding Information: We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.",

year = "2009",

month = aug,

doi = "10.1038/nrc2677",

language = "English",

volume = "9",

pages = "596--604",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "8",

}

TY - JOUR

T1 - Assessing cancer risks of low-dose radiation

AU - Mullenders, Leon

AU - Atkinson, Mike

AU - Paretzke, Herwig

AU - Sabatier, Laure

AU - Bouffler, Simon

N1 - Funding Information: We wish to thank P. Jeggo for critical reading of this manuscript and all RISC-RAD partners for contributing to this research area. Financial support to RISC-RAD is provided by the European Commission under contract FI6R-CT-2003-508,842.

PY - 2009/8

Y1 - 2009/8

N2 - Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

AB - Ionizing radiation is considered a non-threshold carcinogen. However, quantifying the risk of the more commonly encountered low and/or protracted radiation exposures remains problematic and subject to uncertainty. Therefore, a major challenge lies in providing a sound mechanistic understanding of low-dose radiation carcinogenesis. This Perspective article considers whether differences exist between the effects mediated by high- and low-dose radiation exposure and how this affects the assessment of low-dose cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=67749103618&partnerID=8YFLogxK

U2 - 10.1038/nrc2677

DO - 10.1038/nrc2677

M3 - Review article

C2 - 19629073

AN - SCOPUS:67749103618

SN - 1474-175X

VL - 9

SP - 596

EP - 604

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 8

ER -

Assessing cancer risks of low-dose radiation

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this