Antiretroviral pharmacology

Matthew Page, Stephen Taylor

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

There are now >30 antiretroviral medications available for the treatment of HIV. These drugs have distinct sites of action in the HIV life cycle, and unique pharmacological properties that dictate how they can be used safely in the treatment of HIV. Drug–drug interactions (DDIs) can occur because of alterations to several pharmacodynamic processes, including absorption and drug transport, but hepatic metabolism is clinically the most important. Co-administration of antiretrovirals with other, more commonly used drugs is becoming commonplace, and clinicians must be aware of potentially serious interactions that can lead to treatment failure and toxicity.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalMedicine (United Kingdom)
Volume46
Issue number5
DOIs
Publication statusPublished - May 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018

Keywords

  • Antiretrovirals
  • HIV
  • MRCP
  • drug–drug interactions
  • pharmacology

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