Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection

Norman T. Begg; Elizbeth Miller; Christopher K. Fairley; Helen M. Chapel; Helen Griffiths; Pauline A. Waight; L. A.Edward Ashworth

doi:10.1016/0264-410X(95)00091-E

Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection

Norman T. Begg
, Elizbeth Miller
, Christopher K. Fairley^*
, Helen M. Chapel
, Helen Griffiths
, Pauline A. Waight
, L. A.Edward Ashworth

^*Corresponding author for this work

Pillar Testing Staff budget centre

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.

Original language	English
Pages (from-to)	1547-1550
Number of pages	4
Journal	Vaccine
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/0264-410X(95)00091-E
Publication status	Published - 1995

Bibliographical note

Funding Information:
We would like to thank Dr Keith Cartwright and the study nurses in Gloucester and Hertfordshire. The study was funded by the Department of Health, Lederle-Praxis and Pasteur-Merieux. CKF receives a salary from the National Health and Medical Research Council of Australia.

Keywords

Haemophilus influenzae conjugate vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0264-410X(95)00091-E

Cite this

Begg, N. T., Miller, E., Fairley, C. K., Chapel, H. M., Griffiths, H., Waight, P. A., & Ashworth, L. A. E. (1995). Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection. Vaccine, 13(16), 1547-1550. https://doi.org/10.1016/0264-410X(95)00091-E

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abstract = "The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.",

keywords = "Haemophilus influenzae conjugate vaccine",

author = "Begg, \{Norman T.\} and Elizbeth Miller and Fairley, \{Christopher K.\} and Chapel, \{Helen M.\} and Helen Griffiths and Waight, \{Pauline A.\} and Ashworth, \{L. A.Edward\}",

note = "Funding Information: We would like to thank Dr Keith Cartwright and the study nurses in Gloucester and Hertfordshire. The study was funded by the Department of Health, Lederle-Praxis and Pasteur-Merieux. CKF receives a salary from the National Health and Medical Research Council of Australia.",

year = "1995",

doi = "10.1016/0264-410X(95)00091-E",

language = "English",

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pages = "1547--1550",

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Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection. / Begg, Norman T.; Miller, Elizbeth; Fairley, Christopher K. et al.
In: Vaccine, Vol. 13, No. 16, 1995, p. 1547-1550.

Research output: Contribution to journal › Article › peer-review

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T1 - Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection

AU - Begg, Norman T.

AU - Miller, Elizbeth

AU - Fairley, Christopher K.

AU - Chapel, Helen M.

AU - Griffiths, Helen

AU - Waight, Pauline A.

AU - Ashworth, L. A.Edward

N1 - Funding Information: We would like to thank Dr Keith Cartwright and the study nurses in Gloucester and Hertfordshire. The study was funded by the Department of Health, Lederle-Praxis and Pasteur-Merieux. CKF receives a salary from the National Health and Medical Research Council of Australia.

PY - 1995

Y1 - 1995

N2 - The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.

AB - The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P>0.1) while antibody titres to tetanus toxoid were higher in the later group (P<0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.

KW - Haemophilus influenzae conjugate vaccine

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M3 - Article

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AN - SCOPUS:0028879984

SN - 0264-410X

VL - 13

SP - 1547

EP - 1550

JO - Vaccine

JF - Vaccine

IS - 16

ER -

Antibody responses and symptoms after DTP and either tetanus or diphtheria Haemophilus influenzae type B conjugate vaccines given for primary immunisation by separate or mixed injection

Abstract

Bibliographical note

Keywords

UN SDGs

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