Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020

Anna Jeffery-Smith; Nalini Iyanger; Sarah V. Williams; J. Yimmy Chow; Felicity Aiano; Katja Hoschler; Angie Lackenby; Joanna Ellis; Steven Platt; Shahjahan Miah; Kevin Brown; Gayatri Amirthalingam; Monika Patel; Mary Ramsay; Robin Gopal; Andre Charlett; Shamez Ladhani; Maria Zambon

doi:10.2807/1560-7917.ES.2021.26.5.2100092

Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020

Anna Jeffery-Smith^*, Nalini Iyanger, Sarah V. Williams, J. Yimmy Chow, Felicity Aiano, Katja Hoschler, Angie Lackenby, Joanna Ellis, Steven Platt, Shahjahan Miah, Kevin Brown, Gayatri Amirthalingam, Monika Patel, Mary Ramsay, Robin Gopal, Andre Charlett, Shamez Ladhani, Maria Zambon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Two London care homes experienced a second COVID- 19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCRpositive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.

Original language	English
Article number	2100092
Number of pages	6
Journal	Eurosurveillance
Volume	26
Issue number	5
DOIs	https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092
Publication status	Published - 4 Feb 2021

Bibliographical note

Publisher Copyright:
© 2021 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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10.2807/1560-7917.ES.2021.26.5.2100092

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Jeffery-Smith, A., Iyanger, N., Williams, S. V., Chow, J. Y., Aiano, F., Hoschler, K., Lackenby, A., Ellis, J., Platt, S., Miah, S., Brown, K., Amirthalingam, G., Patel, M., Ramsay, M., Gopal, R., Charlett, A., Ladhani, S., & Zambon, M. (2021). Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020. Eurosurveillance, 26(5), Article 2100092. https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092

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abstract = "Two London care homes experienced a second COVID- 19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCRpositive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.",

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Jeffery-Smith, A, Iyanger, N, Williams, SV, Chow, JY, Aiano, F, Hoschler, K , Lackenby, A, Ellis, J, Platt, S, Miah, S, Brown, K , Amirthalingam, G , Patel, M , Ramsay, M , Gopal, R , Charlett, A , Ladhani, S & Zambon, M 2021, 'Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020', Eurosurveillance, vol. 26, no. 5, 2100092. https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092

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AU - Jeffery-Smith, Anna

AU - Iyanger, Nalini

AU - Williams, Sarah V.

AU - Chow, J. Yimmy

AU - Aiano, Felicity

AU - Hoschler, Katja

AU - Lackenby, Angie

AU - Ellis, Joanna

AU - Platt, Steven

AU - Miah, Shahjahan

AU - Brown, Kevin

AU - Amirthalingam, Gayatri

AU - Patel, Monika

AU - Ramsay, Mary

AU - Gopal, Robin

AU - Charlett, Andre

AU - Ladhani, Shamez

AU - Zambon, Maria

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AB - Two London care homes experienced a second COVID- 19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCRpositive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.

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Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020

Abstract

Bibliographical note

UN SDGs

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