TY - JOUR
T1 - Antibacterial prescribing and antibacterial resistance in english general practice
T2 - Cross sectional study
AU - Priest, P.
AU - Yudkin, P.
AU - McNulty, Cliodna
AU - Mant, D.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2001/11/3
Y1 - 2001/11/3
N2 - Objective: To quantify the relation between community based antibacterial prescribing and antibacterial resistance in community acquired disease. Design: Cross sectional study of antibacterial prescribing and antibacterial resistance of routine isolates within individual practices and primary care groups. Setting: 405 general practices (38 groups) in south west and north west England. Main outcome measures: Correlation between antibacterial prescribing and resistance for urinary coliforms and Streptococcus pneumoniae. Results: Antibacterial resistance in urinary coliform isolates is common but the correlation with prescribing rates was relatively low for individual practices (ampicillin and amoxicillin rs = 0.20, P = 0.001; trimethoprim rs = 0.24, P = 0.0001) and primary care groups (ampicillin and amoxicillin rs = 0.44, P = 0.05; trimethoprim rs = 0.31, P = 0.09). Regression coefficients were also low; a practice prescribing 20% less ampicillin and amoxicillin than average would have about 1% fewer resistant isolates (0.94/100; 95% confidence interval 0.02 to 1.85). Resistance of S pneumoniae to both penicillin and erythromycin remains uncommon, and no clear relation with prescribing was found. Conclusions: Routine microbiological isolates should not be used for surveillance of antibacterial resistance in the community or for monitoring the outcome of any change in antibacterial prescribing by general practitioners. Trying to reduce the overall level of antibiotic prescribing in UK general practice may not be the most effective strategy for reducing resistance in the community.
AB - Objective: To quantify the relation between community based antibacterial prescribing and antibacterial resistance in community acquired disease. Design: Cross sectional study of antibacterial prescribing and antibacterial resistance of routine isolates within individual practices and primary care groups. Setting: 405 general practices (38 groups) in south west and north west England. Main outcome measures: Correlation between antibacterial prescribing and resistance for urinary coliforms and Streptococcus pneumoniae. Results: Antibacterial resistance in urinary coliform isolates is common but the correlation with prescribing rates was relatively low for individual practices (ampicillin and amoxicillin rs = 0.20, P = 0.001; trimethoprim rs = 0.24, P = 0.0001) and primary care groups (ampicillin and amoxicillin rs = 0.44, P = 0.05; trimethoprim rs = 0.31, P = 0.09). Regression coefficients were also low; a practice prescribing 20% less ampicillin and amoxicillin than average would have about 1% fewer resistant isolates (0.94/100; 95% confidence interval 0.02 to 1.85). Resistance of S pneumoniae to both penicillin and erythromycin remains uncommon, and no clear relation with prescribing was found. Conclusions: Routine microbiological isolates should not be used for surveillance of antibacterial resistance in the community or for monitoring the outcome of any change in antibacterial prescribing by general practitioners. Trying to reduce the overall level of antibiotic prescribing in UK general practice may not be the most effective strategy for reducing resistance in the community.
UR - http://www.scopus.com/inward/record.url?scp=0035802666&partnerID=8YFLogxK
M3 - Article
C2 - 11691763
AN - SCOPUS:0035802666
SN - 0959-8146
VL - 323
SP - 1037
EP - 1041
JO - British Medical Journal
JF - British Medical Journal
IS - 7320
ER -