Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Sepehr N. Tabrizi; Magnus Unemo; Daniel Golparian; Jimmy Twin; Athena E. Limnios; Monica Lahra; Rebecca Guy

doi:10.1128/JCM.00806-13

Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Sepehr N. Tabrizi^*, Magnus Unemo, Daniel Golparian, Jimmy Twin, Athena E. Limnios, Monica Lahra, Rebecca Guy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.

Original language	English
Pages (from-to)	1945-1947
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	51
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00806-13
Publication status	Published - Jun 2013
Externally published	Yes

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abstract = "GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.",

author = "Tabrizi, {Sepehr N.} and Magnus Unemo and Daniel Golparian and Jimmy Twin and Limnios, {Athena E.} and Monica Lahra and Rebecca Guy",

year = "2013",

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AU - Tabrizi, Sepehr N.

AU - Unemo, Magnus

AU - Golparian, Daniel

AU - Twin, Jimmy

AU - Limnios, Athena E.

AU - Lahra, Monica

AU - Guy, Rebecca

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N2 - GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.

AB - GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.

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AN - SCOPUS:84878485592

SN - 0095-1137

VL - 51

SP - 1945

EP - 1947

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JF - Journal of Clinical Microbiology

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Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Abstract

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