Analysis of host responses of guinea pigs during Helicobacter pylori infection

Sjoerd G. Rijpkema*, Zarmina Durrani, Gary Beavan, Janet R. Gibson, Jane Luck, Robert Owen, Ghazi R. Auda

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    Host responses of guinea pigs infected with Helicobacter pylori were investigated. Passaged H. pylori colonised the stomach for up to 13 weeks after infection, but after 1 month the number of bacteria fell sharply. Specific antibodies, predominantly of the IgG2 subtype, were present from week 3 onwards. Antibodies to urease A and flagella were abundant. Severe inflammation of the gastric mucosa and damage to the stomach epithelium was seen. Infiltrates of mononuclear cells and eosinophils were found near the parietal glands. As infection progressed, inflammation and tissue damage became more localised and more variable between individual animals. These parameters can be used as markers for colonisation of the stomach by H. pylori.

    Original languageEnglish
    Pages (from-to)151-156
    Number of pages6
    JournalFEMS Immunology and Medical Microbiology
    Issue number2
    Publication statusPublished - 2001


    • Guinea pig
    • Helicobacter pylori
    • Immunoglobulin G2
    • Infection model


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