Analysis of host responses of guinea pigs during Helicobacter pylori infection

Sjoerd G. Rijpkema; Zarmina Durrani; Gary Beavan; Janet R. Gibson; Jane Luck; Robert Owen; Ghazi R. Auda

doi:10.1016/S0928-8244(00)00248-0

Analysis of host responses of guinea pigs during Helicobacter pylori infection

Sjoerd G. Rijpkema^*, Zarmina Durrani, Gary Beavan, Janet R. Gibson, Jane Luck, Robert Owen, Ghazi R. Auda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Host responses of guinea pigs infected with Helicobacter pylori were investigated. Passaged H. pylori colonised the stomach for up to 13 weeks after infection, but after 1 month the number of bacteria fell sharply. Specific antibodies, predominantly of the IgG2 subtype, were present from week 3 onwards. Antibodies to urease A and flagella were abundant. Severe inflammation of the gastric mucosa and damage to the stomach epithelium was seen. Infiltrates of mononuclear cells and eosinophils were found near the parietal glands. As infection progressed, inflammation and tissue damage became more localised and more variable between individual animals. These parameters can be used as markers for colonisation of the stomach by H. pylori.

Original language	English
Pages (from-to)	151-156
Number of pages	6
Journal	FEMS Immunology and Medical Microbiology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S0928-8244(00)00248-0
Publication status	Published - 2001

Keywords

Guinea pig
Helicobacter pylori
Immunoglobulin G2
Infection model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0928-8244(00)00248-0

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abstract = "Host responses of guinea pigs infected with Helicobacter pylori were investigated. Passaged H. pylori colonised the stomach for up to 13 weeks after infection, but after 1 month the number of bacteria fell sharply. Specific antibodies, predominantly of the IgG2 subtype, were present from week 3 onwards. Antibodies to urease A and flagella were abundant. Severe inflammation of the gastric mucosa and damage to the stomach epithelium was seen. Infiltrates of mononuclear cells and eosinophils were found near the parietal glands. As infection progressed, inflammation and tissue damage became more localised and more variable between individual animals. These parameters can be used as markers for colonisation of the stomach by H. pylori.",

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AU - Luck, Jane

AU - Owen, Robert

AU - Auda, Ghazi R.

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KW - Immunoglobulin G2

KW - Infection model

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Analysis of host responses of guinea pigs during Helicobacter pylori infection

Abstract

Keywords

UN SDGs

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