An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques

Sally Sharpe*, A. D. White, L. Sibley, F. Gleeson, Graham Hall, R. J. Basaraba, A. McIntyre, Simon Clark, K. Gooch, P. D. Marsh, Ann Williams, Michael Dennis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Background New interventions for tuberculosis are urgently needed. Non-human primate (NHP) models provide the most relevant pre-clinical models of human disease and play a critical role in vaccine development. Models utilising Asian cynomolgus macaque populations are well established but the restricted genetic diversity of the Mauritian cynomolgus macaques may be of added value. Methods Mauritian cynomolgus macaques were exposed to a range of doses of M.Tuberculosis delivered by aerosol, and the outcome was assessed using clinical, imaging and pathologybased measures. Results All macaques developed characteristic clinical signs and disease features of tuberculosis (TB). Disease burden and the ability to control disease were dependent on exposure dose. Mauritian cynomolgus macaques showed less variation in pulmonary disease burden and total gross pathology scores within exposure dose groups than either Indian rhesus macaques or Chinese cynomolgus macaques Conclusions The genetic homogeneity of Mauritian cynomolgus macaques makes them a potentially useful model of human tuberculosis.

Original languageEnglish
Article numbere0171906
JournalPLoS ONE
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2017

Bibliographical note

Funding Information:
This work was supported by the Department of Health, UK. The views expressed in this publication are those of the authors and not necessarily those of the Department of Health. We thank the staff of the Biological Investigations Group at PHE Porton for assistance in conducting studies, Alice Marriott, Charlotte Sarfas and Jenny Gullick for assistance with the immune response analysis and Kim Hatch for histology support.

Publisher Copyright:
© 2017 Sharpe et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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