ADP-ribosylation is a post-translational modification that can be seen in many contexts, including as the primary mechanism of action of many important bacterial exotoxins. By data-mining complete and incomplete bacterial genome sequences, we have discovered >20 novel putative ADP-ribosyltransferases, including several new potential toxins.
Bibliographical noteFunding Information:
We thank the BBSRC for funding the ViruloGenome project. We gratefully acknowledge staff at the Sanger Centre, John Innes Centre, The Institute for Genomic Research, the University of Oklahoma and Genome Therapeutics for making incomplete genome sequence data publicly available.