An abundance of bacterial ADP-ribosyltransferases - Implications for the origin of exotoxins and their human homologues

Mark J. Pallen*, Alex C. Lam, Nicholas J. Loman, Alan McBride

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

62 Citations (Scopus)

Abstract

ADP-ribosylation is a post-translational modification that can be seen in many contexts, including as the primary mechanism of action of many important bacterial exotoxins. By data-mining complete and incomplete bacterial genome sequences, we have discovered >20 novel putative ADP-ribosyltransferases, including several new potential toxins.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalTrends in Microbiology
Volume9
Issue number7
DOIs
Publication statusPublished - 1 Jul 2001
Externally publishedYes

Bibliographical note

Funding Information:
We thank the BBSRC for funding the ViruloGenome project. We gratefully acknowledge staff at the Sanger Centre, John Innes Centre, The Institute for Genomic Research, the University of Oklahoma and Genome Therapeutics for making incomplete genome sequence data publicly available.

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