Alcohol-related cirrhosis - Early abstinence is a key factor in prognosis, even in the most severe cases

Clare Verrill*, Hannah Markham, Alexa Templeton, Norman J. Carr, Nick Sheron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Aims To determine the effect of pathological severity of cirrhosis on survival in patients with alcohol-related cirrhosis. Design Liver biopsies from 100 patients were scored for Laennec score of severity of cirrhosis, and medical notes were reviewed to determine various clinical factors, including drinking status. Up-to-date mortality data were obtained using the National Health Service Strategic Tracing Service. Setting Southampton General Hospital between 1 January 1995 and 31 December 2000. Participants A total of 100 consecutive patients with biopsy proven alcohol-induced liver cirrhosis. Measurements Laennec score of severity of cirrhosis and mortality. Findings Most surprisingly, the severity of cirrhosis on biopsy had little impact on survival; indeed, early death was more likely in patients with the least severe cirrhosis. Abstinence from alcohol at 1 month after diagnosis of cirrhosis was the more important factor determining survival with a 7-year survival of 72% for the abstinent patients versus 44% for the patients continuing to drink. Conclusions It is never too late to stop drinking, even with the most severe degrees of cirrhosis on biopsy. Early drinking status is the most important factor determining long-term survival in alcohol-related cirrhosis.

Original languageEnglish
Pages (from-to)768-774
Number of pages7
JournalAddiction
Volume104
Issue number5
DOIs
Publication statusPublished - May 2009
Externally publishedYes

Keywords

  • Abstinence
  • Alcohol
  • Cirrhosis
  • Grading
  • Mortality
  • Pathology

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