Age-Specific Incidence Rates for Norovirus in the Community and Presenting to Primary Healthcare Facilities in the United Kingdom

Sarah J. O'Brien; Anna L. Donaldson; Miren Iturriza-Gomara; Clarence C. Tam

doi:10.1093/infdis/jiv411

Age-Specific Incidence Rates for Norovirus in the Community and Presenting to Primary Healthcare Facilities in the United Kingdom

Sarah J. O'Brien^*, Anna L. Donaldson, Miren Iturriza-Gomara, Clarence C. Tam

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

In a prospective, population-based cohort study and a study of primary-healthcare consultations, we had a rare opportunity to estimate age-specific rates of norovirus-associated infectious intestinal disease in the United Kingdom. Rates in children aged <5 years were significantly higher than those for other age groups in the community (142.6 cases per 1000 person-years [95% confidence interval {CI}, 99.8-203.9] vs 37.6 [95% CI, 31.5-44.7]) and those for individuals presenting to primary healthcare (14.4 cases per 1000 person-years [95% CI, 8.5-24.5] vs 1.4 [95% CI,. 9-2.0]). Robust incidence estimates are crucial for vaccination policy makers. This study emphasises the impact of norovirus-associated infectious intestinal disease, especially in children aged <5 years.

Original language	English
Pages (from-to)	S15-S18
Journal	Journal of Infectious Diseases
Volume	213
DOIs	https://doi.org/10.1093/infdis/jiv411
Publication status	Published - 1 Feb 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 The Author.

Keywords

acute gastroenteritis
community
incidence
norovirus
pediatric
policy
prevention
primary healthcare
real-time/quantitative RT-PCR
vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiv411

Cite this

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title = "Age-Specific Incidence Rates for Norovirus in the Community and Presenting to Primary Healthcare Facilities in the United Kingdom",

abstract = "In a prospective, population-based cohort study and a study of primary-healthcare consultations, we had a rare opportunity to estimate age-specific rates of norovirus-associated infectious intestinal disease in the United Kingdom. Rates in children aged <5 years were significantly higher than those for other age groups in the community (142.6 cases per 1000 person-years [95% confidence interval {CI}, 99.8-203.9] vs 37.6 [95% CI, 31.5-44.7]) and those for individuals presenting to primary healthcare (14.4 cases per 1000 person-years [95% CI, 8.5-24.5] vs 1.4 [95% CI,. 9-2.0]). Robust incidence estimates are crucial for vaccination policy makers. This study emphasises the impact of norovirus-associated infectious intestinal disease, especially in children aged <5 years.",

keywords = "acute gastroenteritis, community, incidence, norovirus, pediatric, policy, prevention, primary healthcare, real-time/quantitative RT-PCR, vaccination",

author = "O'Brien, {Sarah J.} and Donaldson, {Anna L.} and Miren Iturriza-Gomara and Tam, {Clarence C.}",

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AU - O'Brien, Sarah J.

AU - Donaldson, Anna L.

AU - Iturriza-Gomara, Miren

AU - Tam, Clarence C.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - In a prospective, population-based cohort study and a study of primary-healthcare consultations, we had a rare opportunity to estimate age-specific rates of norovirus-associated infectious intestinal disease in the United Kingdom. Rates in children aged <5 years were significantly higher than those for other age groups in the community (142.6 cases per 1000 person-years [95% confidence interval {CI}, 99.8-203.9] vs 37.6 [95% CI, 31.5-44.7]) and those for individuals presenting to primary healthcare (14.4 cases per 1000 person-years [95% CI, 8.5-24.5] vs 1.4 [95% CI,. 9-2.0]). Robust incidence estimates are crucial for vaccination policy makers. This study emphasises the impact of norovirus-associated infectious intestinal disease, especially in children aged <5 years.

AB - In a prospective, population-based cohort study and a study of primary-healthcare consultations, we had a rare opportunity to estimate age-specific rates of norovirus-associated infectious intestinal disease in the United Kingdom. Rates in children aged <5 years were significantly higher than those for other age groups in the community (142.6 cases per 1000 person-years [95% confidence interval {CI}, 99.8-203.9] vs 37.6 [95% CI, 31.5-44.7]) and those for individuals presenting to primary healthcare (14.4 cases per 1000 person-years [95% CI, 8.5-24.5] vs 1.4 [95% CI,. 9-2.0]). Robust incidence estimates are crucial for vaccination policy makers. This study emphasises the impact of norovirus-associated infectious intestinal disease, especially in children aged <5 years.

KW - acute gastroenteritis

KW - community

KW - incidence

KW - norovirus

KW - pediatric

KW - policy

KW - prevention

KW - primary healthcare

KW - real-time/quantitative RT-PCR

KW - vaccination

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JF - Journal of Infectious Diseases

ER -

Age-Specific Incidence Rates for Norovirus in the Community and Presenting to Primary Healthcare Facilities in the United Kingdom

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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