Age disparities in stage-specific colon cancer survival across seven countries: An International Cancer Benchmarking Partnership SURVMARK-2 population-based study

Sophie Pilleron*, Hadrien Charvat, Marzieh Araghi, Melina Arnold, Miranda M. Fidler-Benaoudia, Aude Bardot, Marianne Grønlie Guren, Hanna Tervonen, Alana Little, Dianne L. O'Connell, Anna Gavin, Prithwish De, Linda Aagard Thomsen, Bjørn Møller, Christopher Jackson, Oliver Bucher, Paul M. Walsh, Sally Vernon, Freddie Bray, Isabelle Soerjomataram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We sought to understand the role of stage at diagnosis in observed age disparities in colon cancer survival among people aged 50 to 99 years using population-based cancer registry data from seven high-income countries: Australia, Canada, Denmark, Ireland, New Zealand, Norway and the United Kingdom. We used colon cancer incidence data for the period 2010 to 2014. We estimated the 3-year net survival, as well as the 3-year net survival conditional on surviving at least 6 months and 1 year after diagnosis, by country and stage at diagnosis (categorised as localised, regional or distant) using flexible parametric excess hazard regression models. In all countries, increasing age was associated with lower net survival. For example, 3-year net survival (95% confidence interval) was 81% (80-82) for 50 to 64 year olds and 58% (56-60) for 85 to 99 year olds in Australia, and 74% (73-74) and 39% (39-40) in the United Kingdom, respectively. Those with distant stage colon cancer had the largest difference in colon cancer survival between the youngest and the oldest patients. Excess mortality for the oldest patients with localised or regional cancers was observed during the first 6 months after diagnosis. Older patients diagnosed with localised (and in some countries regional) stage colon cancer who survived 6 months after diagnosis experienced the same survival as their younger counterparts. Further studies examining other prognostic clinical factors such as comorbidities and treatment, and socioeconomic factors are warranted to gain further understanding of the age disparities in colon cancer survival.

Original languageEnglish
Pages (from-to)1575-1585
Number of pages11
JournalInternational Journal of Cancer
Volume148
Issue number7
DOIs
Publication statusPublished - 1 Apr 2021

Bibliographical note

Funding Information:
We would like to thank Lucie Hooper, Samantha Harrison, Charles Norell, Shanta Keshwala, Charlotte Lynch, Deborah Robinson and Irene Reguilon of Cancer Research UK for managing the programme. We would also like to thank the ICBP Local Leads, ICBP Programme Board and ICBP Clinical Committees for their continuing support and advice, and the ICBP SurvMark-2 Academic Reference Group for providing independent peer review and advice for the study protocol and analysis plan development. Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer/World Health Organization. This work was supported by Canadian Partnership Against Cancer; Cancer Council Victoria; Cancer Institute New South Wales; Cancer Research UK; Danish Cancer Society; National Cancer Registry Ireland; The Cancer Society of New Zealand; NHS England; Norwegian Cancer Society; Public Health Agency Northern Ireland, on behalf of the Northern Ireland Cancer Registry; The Scottish Government; Western Australia Department of Health; and the Wales Cancer Network. The work completed in this manuscript was undertaken while Sophie Pilleron was a postdoctoral fellow at the International Agency for Research on Cancer, which was partially funded by the European Commission's Seventh Framework Programme Marie Curie Actions?People?COFUND.

Funding Information:
This work was supported by Canadian Partnership Against Cancer; Cancer Council Victoria; Cancer Institute New South Wales; Cancer Research UK; Danish Cancer Society; National Cancer Registry Ireland; The Cancer Society of New Zealand; NHS England; Norwegian Cancer Society; Public Health Agency Northern Ireland, on behalf of the Northern Ireland Cancer Registry; The Scottish Government; Western Australia Department of Health; and the Wales Cancer Network. The work completed in this manuscript was undertaken while Sophie Pilleron was a postdoctoral fellow at the International Agency for Research on Cancer, which was partially funded by the European Commission's Seventh Framework Programme Marie Curie Actions—People—COFUND.

Publisher Copyright:
© 2020 Union for International Cancer Control

Keywords

  • cancer survival
  • epidemiology
  • older adults
  • population-based cancer registry

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