TY - JOUR
T1 - Age-associated defect in ADCC response to COVID-19 vaccine
AU - The CITIID-NIHR BioResource COVID-19 Collaboration
AU - Sievers, Benjamin L.
AU - Altaf, Mazharul
AU - Cheng, Mark T.K.
AU - Kamelian, Kimia
AU - Cormie, Claire
AU - Williamson, Kate
AU - Hosseini, Zhaleh
AU - Spencer, Sarah
AU - Mulroney, Thomas
AU - Gurugama, Lihinya
AU - Gurugama, Thevinya
AU - Rust, Maria
AU - Beristain-Covarrubias, Nonantzin
AU - Puc, Juan Carlos Yam
AU - Hughes, Robert
AU - Boston, Rebecca
AU - Ferreira, Alexander
AU - Booth, Lucy
AU - Horner, Emily C.
AU - Yakovleva, Anna
AU - Pinckert, Malte L.
AU - Parmar, Surendra
AU - Meredith, Luke W.
AU - Kovalenko, Anna G.
AU - Khokhar, Fahad A.
AU - Jahun, Aminu S.
AU - Izuagbe, Rhys
AU - Houldcroft, Charlotte J.
AU - Hosmillo, Myra
AU - Hamilton, William L.
AU - Hall, Grant
AU - Georgana, Iliana
AU - Fuller, Stewart
AU - Feltwell, Theresa
AU - Curran, Martin D.
AU - Chaudhry, Yasmin
AU - Caller, Laura G.
AU - Caddy, Sarah L.
AU - Polgarova, Petra
AU - Webster, Jennifer
AU - Walker, Neil
AU - Townsend, Paul
AU - Stirrups, Kathleen E.
AU - Schon, Katherine
AU - Sambrook, Jennifer
AU - Sage, Abigail
AU - Paraschiv, Roxana
AU - Ranganath, Venkatesh
AU - Phelan, Isabel
AU - Penkett, Christopher J.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.
AB - We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.
UR - https://www.scopus.com/pages/publications/105012436192
UR - https://www.mendeley.com/catalogue/7f665416-1ae0-3cf3-8250-93243d600252/
U2 - 10.1038/s41541-025-01196-9
DO - 10.1038/s41541-025-01196-9
M3 - Article
AN - SCOPUS:105012436192
SN - 2059-0105
VL - 10
JO - npj Vaccines
JF - npj Vaccines
IS - 1
M1 - 132
ER -
