Advances in the development of vaccines against Neisseria meningitidis

Lionel K.K. Tan; George M. Carlone; Raymond Borrow

doi:10.1056/NEJMra0906357

Advances in the development of vaccines against Neisseria meningitidis

Lionel K.K. Tan, George M. Carlone, Raymond Borrow^*

^*Corresponding author for this work

Manchester Meningococcal Reference Unit General

Research output: Contribution to journal › Review article › peer-review

207 Citations (Scopus)

Abstract

Neisseria meningitidis remains a leading cause of meningitis and sepsis. This review provides an update on our understanding of immunity against meningococcal infection. Knowledge of the meningococcal genome has led to identification of novel antigens. A major challenge is to improve the immunogenicity of vaccines in infants, who are especially vulnerable to this infection.

Original language	English
Pages (from-to)	1511
Number of pages	1
Journal	New England Journal of Medicine
Volume	362
Issue number	16
DOIs	https://doi.org/10.1056/NEJMra0906357
Publication status	Published - 22 Apr 2010

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10.1056/NEJMra0906357

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title = "Advances in the development of vaccines against Neisseria meningitidis",

abstract = "Neisseria meningitidis remains a leading cause of meningitis and sepsis. This review provides an update on our understanding of immunity against meningococcal infection. Knowledge of the meningococcal genome has led to identification of novel antigens. A major challenge is to improve the immunogenicity of vaccines in infants, who are especially vulnerable to this infection.",

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AB - Neisseria meningitidis remains a leading cause of meningitis and sepsis. This review provides an update on our understanding of immunity against meningococcal infection. Knowledge of the meningococcal genome has led to identification of novel antigens. A major challenge is to improve the immunogenicity of vaccines in infants, who are especially vulnerable to this infection.

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Advances in the development of vaccines against Neisseria meningitidis

Abstract

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