Advances and gaps in SARS-CoV-2 infection models

César Muñoz-Fontela, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie de Wit, Michael S. Diamond, William E. Dowling, Simon G.P. Funnell, Adolfo García-Sastre, Nora M. Gerhards, Rineke de Jong, Vincent J. Munster, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Ximena Riveros-Balta, Chad J. Roy, Francisco J. SalgueroMichael Schotsaert, Lauren M. Schwartz, Robert A. Seder, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo, Dan H. Barouch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
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Abstract

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.
Original languageEnglish
Article numbere1010161
JournalPLoS Pathogens
Volume18
Issue number1
DOIs
Publication statusPublished - 13 Jan 2022

Bibliographical note

Funding information: The authors received no specific funding for this work.

Open Access: The work is made available under the Creative Commons CC0 public domain dedication.

Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Citation: Muñoz-Fontela C, Widerspick L, Albrecht RA, Beer M, Carroll MW, de Wit E, et al. (2022) Advances and gaps in SARS-CoV-2 infection models. PLoS Pathog 18(1): e1010161.

DOI: https://doi. org/10.1371/journal.ppat.1010161

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