Advances and gaps in SARS-CoV-2 infection models

César Muñoz-Fontela; Lina Widerspick; Randy A. Albrecht; Martin Beer; Miles W. Carroll; Emmie de Wit; Michael S. Diamond; William E. Dowling; Simon G.P. Funnell; Adolfo García-Sastre; Nora M. Gerhards; Rineke de Jong; Vincent J. Munster; Johan Neyts; Stanley Perlman; Douglas S. Reed; Juergen A. Richt; Ximena Riveros-Balta; Chad J. Roy; Francisco J. Salguero; Michael Schotsaert; Lauren M. Schwartz; Robert A. Seder; Joaquim Segalés; Seshadri S. Vasan; Ana María Henao-Restrepo; Dan H. Barouch

doi:10.1371/journal.ppat.1010161

Advances and gaps in SARS-CoV-2 infection models

César Muñoz-Fontela, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie de Wit, Michael S. Diamond, William E. Dowling, Simon G.P. Funnell, Adolfo García-Sastre, Nora M. Gerhards, Rineke de Jong, Vincent J. Munster, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Ximena Riveros-Balta, Chad J. Roy, Francisco J. SalgueroMichael Schotsaert, Lauren M. Schwartz, Robert A. Seder, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo, Dan H. Barouch^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

Original language	English
Article number	e1010161
Journal	PLoS Pathogens
Volume	18
Issue number	1
DOIs	https://doi.org/10.1371/journal.ppat.1010161
Publication status	Published - 13 Jan 2022

Bibliographical note

Funding information: The authors received no specific funding for this work.

Open Access: The work is made available under the Creative Commons CC0 public domain dedication.

Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Citation: Muñoz-Fontela C, Widerspick L, Albrecht RA, Beer M, Carroll MW, de Wit E, et al. (2022) Advances and gaps in SARS-CoV-2 infection models. PLoS Pathog 18(1): e1010161.

DOI: https://doi. org/10.1371/journal.ppat.1010161

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Muñoz-Fontela, C., Widerspick, L., Albrecht, R. A., Beer, M., Carroll, M. W., de Wit, E., Diamond, M. S., Dowling, W. E., Funnell, S. G. P., García-Sastre, A., Gerhards, N. M., de Jong, R., Munster, V. J., Neyts, J., Perlman, S., Reed, D. S., Richt, J. A., Riveros-Balta, X., Roy, C. J., ... Barouch, D. H. (2022). Advances and gaps in SARS-CoV-2 infection models. PLoS Pathogens, 18(1), Article e1010161. https://doi.org/10.1371/journal.ppat.1010161

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title = "Advances and gaps in SARS-CoV-2 infection models",

abstract = "The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.",

author = "C{\'e}sar Mu{\~n}oz-Fontela and Lina Widerspick and Albrecht, {Randy A.} and Martin Beer and Carroll, {Miles W.} and {de Wit}, Emmie and Diamond, {Michael S.} and Dowling, {William E.} and Funnell, {Simon G.P.} and Adolfo Garc{\'i}a-Sastre and Gerhards, {Nora M.} and {de Jong}, Rineke and Munster, {Vincent J.} and Johan Neyts and Stanley Perlman and Reed, {Douglas S.} and Richt, {Juergen A.} and Ximena Riveros-Balta and Roy, {Chad J.} and Salguero, {Francisco J.} and Michael Schotsaert and Schwartz, {Lauren M.} and Seder, {Robert A.} and Joaquim Segal{\'e}s and Vasan, {Seshadri S.} and Henao-Restrepo, {Ana Mar{\'i}a} and Barouch, {Dan H.}",

note = "Funding information: The authors received no specific funding for this work. Open Access: The work is made available under the Creative Commons CC0 public domain dedication. Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Citation: Mu{\~n}oz-Fontela C, Widerspick L, Albrecht RA, Beer M, Carroll MW, de Wit E, et al. (2022) Advances and gaps in SARS-CoV-2 infection models. PLoS Pathog 18(1): e1010161. DOI: https://doi. org/10.1371/journal.ppat.1010161",

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Muñoz-Fontela, C, Widerspick, L, Albrecht, RA, Beer, M, Carroll, MW, de Wit, E, Diamond, MS, Dowling, WE, Funnell, SGP, García-Sastre, A, Gerhards, NM, de Jong, R, Munster, VJ, Neyts, J, Perlman, S, Reed, DS, Richt, JA, Riveros-Balta, X, Roy, CJ, Salguero, FJ, Schotsaert, M, Schwartz, LM, Seder, RA, Segalés, J, Vasan, SS, Henao-Restrepo, AM & Barouch, DH 2022, 'Advances and gaps in SARS-CoV-2 infection models', PLoS Pathogens, vol. 18, no. 1, e1010161. https://doi.org/10.1371/journal.ppat.1010161

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T1 - Advances and gaps in SARS-CoV-2 infection models

AU - Muñoz-Fontela, César

AU - Widerspick, Lina

AU - Albrecht, Randy A.

AU - Beer, Martin

AU - Carroll, Miles W.

AU - de Wit, Emmie

AU - Diamond, Michael S.

AU - Dowling, William E.

AU - Funnell, Simon G.P.

AU - García-Sastre, Adolfo

AU - Gerhards, Nora M.

AU - de Jong, Rineke

AU - Munster, Vincent J.

AU - Neyts, Johan

AU - Perlman, Stanley

AU - Reed, Douglas S.

AU - Richt, Juergen A.

AU - Riveros-Balta, Ximena

AU - Roy, Chad J.

AU - Salguero, Francisco J.

AU - Schotsaert, Michael

AU - Schwartz, Lauren M.

AU - Seder, Robert A.

AU - Segalés, Joaquim

AU - Vasan, Seshadri S.

AU - Henao-Restrepo, Ana María

AU - Barouch, Dan H.

N1 - Funding information: The authors received no specific funding for this work. Open Access: The work is made available under the Creative Commons CC0 public domain dedication. Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Citation: Muñoz-Fontela C, Widerspick L, Albrecht RA, Beer M, Carroll MW, de Wit E, et al. (2022) Advances and gaps in SARS-CoV-2 infection models. PLoS Pathog 18(1): e1010161. DOI: https://doi. org/10.1371/journal.ppat.1010161

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AB - The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.

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U2 - 10.1371/journal.ppat.1010161

DO - 10.1371/journal.ppat.1010161

M3 - Review article

AN - SCOPUS:85123322020

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VL - 18

JO - PLoS Pathogens

JF - PLoS Pathogens

IS - 1

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ER -

Advances and gaps in SARS-CoV-2 infection models

Abstract

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