Abstract
Ionizing radiation (IR) is a well-characterized carcinogen in humans and mice. The BALB/c mouse strain is unusually sensitive to IR-induced tissue damage and cancer development in a range of organs, suggestive of a partial defect in DNA damage response. This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase. PrkdcBALB has been associated with increased susceptibility to IR-induced mammary and lymphatic neoplasia. Here, we provide evidence that chromosome 16 segments from BALB/c interact with ApcMin (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine.
Original language | English |
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Pages (from-to) | 2361-2363 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 63 |
Issue number | 10 |
Publication status | Published - 15 May 2003 |