Addressing frailty in patients with breast cancer: A review of the literature

Yasmin Jauhari*, Melissa Ruth Gannon, David Dodwell, Kieran Horgan, Carmen Tsang, Karen Baker, Jibby Medina, Sarah Tang, Ruth Pettengell, David Alan Cromwell

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Various studies have documented variation in the management of older patients with breast cancer, and some of this variation stems from different approaches to balancing the expected benefit of different treatments, with the ability of patients to tolerate them. Frailty is an emerging concept that can help to make clinical decisions for older patients more consistent, not least by providing a measure of ‘biological’ ageing. This would reduce reliance on ‘chronological’ age, which is not a reliable guide for decisions on the appropriate breast cancer care for older patients. This article examines the potential of frailty assessment to inform on breast cancer treatments. Overall, the current evidence highlights various benefits from implementing comprehensive geriatric assessment and screening for frailty in breast cancer patients. This includes a role in supporting the selection of appropriate therapies and improving physical fitness prior to treatment. However, there are challenges in implementing routine frailty assessments in a breast cancer service. Studies have used a diverse array of frailty assessment instruments, which hampers the generalisability of research findings. Consequently, a number of issues need to be addressed to clearly establish the optimal timing of frailty assessment and the role of geriatric medicine specialists in the breast cancer care pathway.

Original languageEnglish
JournalEuropean Journal of Surgical Oncology
Publication statusAccepted/In press - 2019

Bibliographical note

Funding Information:
This review was undertaken as part of the work by the National Audit of Breast Cancer in Older Patients (NABCOP). The Audit is commissioned by the Healthcare Quality Improvement Partnership (HQIP) as part of the National Clinical Audit and Patient Outcomes Programme (NCAPOP), and funded by NHS England and the Welsh Government ( ). Neither HQIP nor the funders had any involvement in the design of this review or in the identification, and interpretation of published literature, in the writing of the report, or in the decision to submit the article for publication. The authors had full independence from the HQIP.

Publisher Copyright:
© 2019


  • Breast cancer
  • Elderly
  • Frailty
  • Review


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