Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis

Ann S. McDermid; P. D. Marsh; C. W. Keevil; D. C. Ellwood

doi:10.1159/000260830

Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis

Ann S. McDermid
, P. D. Marsh^*
, C. W. Keevil
, D. C. Ellwood

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.

Original language	English
Pages (from-to)	64-71
Number of pages	8
Journal	Caries Research
Volume	19
Issue number	1
DOIs	https://doi.org/10.1159/000260830
Publication status	Published - 1985

Keywords

Acid production, bacterial
Chlorhexidine
Fluoride
Streptococcus mutans
Streptococcus sanguis

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10.1159/000260830

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title = "Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis",

abstract = "The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.",

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T1 - Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis

AU - McDermid, Ann S.

AU - Marsh, P. D.

AU - Keevil, C. W.

AU - Ellwood, D. C.

PY - 1985

Y1 - 1985

N2 - The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.

AB - The effect of 0.07 or 0.15 mMchlorhexidine (CHX) and 4.0 or 8.0 mM potassium fluoride (F), added singly and in combinations, on acid production by Streptococcus mutans and Streptococcus sanguis was studied. Cells were grown in a chemostat under different environmental conditions and acid production from glucose or sucrose was measured as a rate at pH 7.0 and by pH-fall experiments. CHX had a greater inhibitory action on S. mutans while S. sanguis was more sensitive to F. Growth conditions affected the sensitivity of both strains to the two inhibitors and, in general, cells grown glucose-limited were the most sensitive. Combinations of F and CHX showed additive inhibitory effects on acid production, irrespective of the method of measurement.

KW - Acid production, bacterial

KW - Chlorhexidine

KW - Fluoride

KW - Streptococcus mutans

KW - Streptococcus sanguis

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DO - 10.1159/000260830

M3 - Article

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AN - SCOPUS:0021927454

SN - 0008-6568

VL - 19

SP - 64

EP - 71

JO - Caries Research

JF - Caries Research

IS - 1

ER -

Additive inhibitory effects of combinations of fluoride and chlorhexidine on acid production by Streptococcus mutans and Streptococcus sanguis

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