Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains

Sandra Ratzow, Valeria Gaia, Jürgen Herbert Helbig, Norman Fry, Paul Christian Lück*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

202 Citations (Scopus)

Abstract

The standard sequence-based method for the typing of Legionella pneumophila serogroup 1 strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.

Original languageEnglish
Pages (from-to)1965-1968
Number of pages4
JournalJournal of Clinical Microbiology
Volume45
Issue number6
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Dive into the research topics of 'Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains'. Together they form a unique fingerprint.

Cite this