Acute limb deterioration during intra‐arterial thrombolysis

R. B. Galland*, J. J. Earnshaw, R. N. Baird, R. J. Lonsdale, B. R. Hopkinson, A. E.B. Giddings, K. J. Dawson, G. Hamilton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Approximately 12 per cent of limbs undergoing intra‐arterial thrombolysis (IAT) develop distal embolism or extension of thrombus during the procedure. These are usually of little clinical consequence and can be treated by increasing the rate of administration of the lytic agent. However, in some patients the clinical condition of the limb deteriorates rapidly. In an attempt to define the incidence of acute limb deterioration during IAT, information was collected from five centres in the UK with experience of the technique. A total of 866 treatments were recorded, with 20 limbs (2·3 per cent) undergoing acute deterioration. This complication was more common during the treatment of thrombosed popliteal aneurysm than during that of emboli or thrombosed atheromatous arteries or grafts (P <0·001). The amputation rate associated with the complication was high, and operative intervention provided better results than continuation of lysis.

Original languageEnglish
Pages (from-to)1118-1120
Number of pages3
JournalBritish Journal of Surgery
Issue number9
Publication statusPublished - Sept 1993
Externally publishedYes


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