ACUTE ENCEPHALOPATHY COINCIDENT WITH SEROCONVERSION FOR ANTI-HTLV-III

C. A. Carne; Ann Smith; S. G. Elkington; F. E. Preston; R. S. Tedder; Sheena Sutherland; Helena M. Daly; J. Craske

doi:10.1016/S0140-6736(85)90740-8

ACUTE ENCEPHALOPATHY COINCIDENT WITH SEROCONVERSION FOR ANTI-HTLV-III

C. A. Carne^*, Ann Smith, S. G. Elkington, F. E. Preston, R. S. Tedder, Sheena Sutherland, Helena M. Daly, J. Craske

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

222 Citations (Scopus)

Abstract

Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, characterised by pyrexia, general malaise, and changes of mood. The encephalopathy culminated in epileptiform seizures in two of the patients. Electroencephalographic changes were compatible with viral encephalitis, and cerebrospinal-fluid pleocytosis was minimal. Neurological signs and symptoms resolved quickly in all patients, and no residual central-nervous-system sequelae were apparent.

Original language	English
Pages (from-to)	1206-1208
Number of pages	3
Journal	The Lancet
Volume	326
Issue number	8466
DOIs	https://doi.org/10.1016/S0140-6736(85)90740-8
Publication status	Published - 30 Nov 1985
Externally published	Yes

Bibliographical note

Funding Information:
Duncan, Laboratories, Wellcome Foundation, for provision of HTLV-III-mfected for provision ofHRPO/anti-HTLV-III, cells (CEM.CBL1) Dr andJ. our many colleagues who provided additional data and helpful discussions. This study was supported in some part by the Medical Research Council. Correspondence should be addressed to R. S. T., School of Pathology, Middlesex Hospital Medical School, Ridmg House Street, London W 1 P 7PN.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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10.1016/S0140-6736(85)90740-8

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@article{2c30c68424294de38c4c7378e6d08562,

title = "ACUTE ENCEPHALOPATHY COINCIDENT WITH SEROCONVERSION FOR ANTI-HTLV-III",

abstract = "Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, characterised by pyrexia, general malaise, and changes of mood. The encephalopathy culminated in epileptiform seizures in two of the patients. Electroencephalographic changes were compatible with viral encephalitis, and cerebrospinal-fluid pleocytosis was minimal. Neurological signs and symptoms resolved quickly in all patients, and no residual central-nervous-system sequelae were apparent.",

author = "Carne, {C. A.} and Ann Smith and Elkington, {S. G.} and Preston, {F. E.} and Tedder, {R. S.} and Sheena Sutherland and Daly, {Helena M.} and J. Craske",

note = "Funding Information: Duncan, Laboratories, Wellcome Foundation, for provision of HTLV-III-mfected for provision ofHRPO/anti-HTLV-III, cells (CEM.CBL1) Dr andJ. our many colleagues who provided additional data and helpful discussions. This study was supported in some part by the Medical Research Council. Correspondence should be addressed to R. S. T., School of Pathology, Middlesex Hospital Medical School, Ridmg House Street, London W 1 P 7PN. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1985",

month = nov,

day = "30",

doi = "10.1016/S0140-6736(85)90740-8",

language = "English",

volume = "326",

pages = "1206--1208",

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T1 - ACUTE ENCEPHALOPATHY COINCIDENT WITH SEROCONVERSION FOR ANTI-HTLV-III

AU - Carne, C. A.

AU - Smith, Ann

AU - Elkington, S. G.

AU - Preston, F. E.

AU - Tedder, R. S.

AU - Sutherland, Sheena

AU - Daly, Helena M.

AU - Craske, J.

N1 - Funding Information: Duncan, Laboratories, Wellcome Foundation, for provision of HTLV-III-mfected for provision ofHRPO/anti-HTLV-III, cells (CEM.CBL1) Dr andJ. our many colleagues who provided additional data and helpful discussions. This study was supported in some part by the Medical Research Council. Correspondence should be addressed to R. S. T., School of Pathology, Middlesex Hospital Medical School, Ridmg House Street, London W 1 P 7PN. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1985/11/30

Y1 - 1985/11/30

N2 - Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, characterised by pyrexia, general malaise, and changes of mood. The encephalopathy culminated in epileptiform seizures in two of the patients. Electroencephalographic changes were compatible with viral encephalitis, and cerebrospinal-fluid pleocytosis was minimal. Neurological signs and symptoms resolved quickly in all patients, and no residual central-nervous-system sequelae were apparent.

AB - Acute encephalopathy was associated with the appearance of antibodies to human T-lymphotropic virus (HTLV-III) in two patients. A third patient showed seroconversion for anti-HTLV-III, but the temporal association was not established so precisely. The illness was characterised by a prodromal period of up to 2 weeks, characterised by pyrexia, general malaise, and changes of mood. The encephalopathy culminated in epileptiform seizures in two of the patients. Electroencephalographic changes were compatible with viral encephalitis, and cerebrospinal-fluid pleocytosis was minimal. Neurological signs and symptoms resolved quickly in all patients, and no residual central-nervous-system sequelae were apparent.

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JO - The Lancet

JF - The Lancet

IS - 8466

ER -

ACUTE ENCEPHALOPATHY COINCIDENT WITH SEROCONVERSION FOR ANTI-HTLV-III

Abstract

Bibliographical note

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