Activity of daptomycin against multi-resistant Gram-positive bacteria including enterococci and Staphylococcus aureus resistant to linezolid

Alan Johnson*, Shazad Mushtaq, Marina Warner, David Livermore

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, β-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were ≤1 mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were ≤2 and ≤4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume24
Issue number4
DOIs
Publication statusPublished - Oct 2004

Bibliographical note

Funding Information:
This work was supported by Cubist Pharmaceuticals, Lexington, MA, USA.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Coryneforms
  • Daptomycin
  • Enterococci
  • Staphylococci
  • Streptococci
  • Susceptibility testing

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