TY - JOUR
T1 - Accelerating control of pertussis in England and Wales
AU - Campbell, Helen
AU - Amirthalingam, Gayatri
AU - Andrews, Nicholas
AU - Fry, Norman
AU - George, Robert
AU - Harrison, Timothy
AU - Miller, Elizbeth
PY - 2012/1
Y1 - 2012/1
N2 - Results of an accelerated pertussis vaccination schedule introduced in 1990 for infants in England and Wales were examined. Earlier scheduling and sustained high vaccine coverage resulted in fewer reported cases of pertussis among infants, reinforcing the World Health Organization drive for on-time completion of the infant vaccination schedule. As determined by using the screening method, the first dose of vaccine was 61.7% effective in infants <6 months of age, and effectiveness increased with subsequent doses. Three doses of a good whole-cell pertussis vaccine were 83.7% effective in children 10-16 years of age; a preschool booster vaccination further reduced pertussis incidence in children <10 years of age. As in other industrialized countries, surveillance data during 1998-2009 showed that pertussis in England and Wales mainly persists in young infants (i.e., <3 months of age), teenagers, and adults. Future vaccine program changes may be beneficial, but additional detail is required to inform such decisions.
AB - Results of an accelerated pertussis vaccination schedule introduced in 1990 for infants in England and Wales were examined. Earlier scheduling and sustained high vaccine coverage resulted in fewer reported cases of pertussis among infants, reinforcing the World Health Organization drive for on-time completion of the infant vaccination schedule. As determined by using the screening method, the first dose of vaccine was 61.7% effective in infants <6 months of age, and effectiveness increased with subsequent doses. Three doses of a good whole-cell pertussis vaccine were 83.7% effective in children 10-16 years of age; a preschool booster vaccination further reduced pertussis incidence in children <10 years of age. As in other industrialized countries, surveillance data during 1998-2009 showed that pertussis in England and Wales mainly persists in young infants (i.e., <3 months of age), teenagers, and adults. Future vaccine program changes may be beneficial, but additional detail is required to inform such decisions.
UR - http://www.scopus.com/inward/record.url?scp=84856579446&partnerID=8YFLogxK
U2 - 10.3201/eid1801.110784
DO - 10.3201/eid1801.110784
M3 - Article
C2 - 22260989
AN - SCOPUS:84856579446
SN - 1080-6040
VL - 18
SP - 38
EP - 47
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 1
ER -