Absorption kinetics of uranium tri-n-butyl phosphate in the rat: Implications for occupational exposure

P. G. Pellow*, G. N. Stradling, Alan Hodgson, Timothy Fell, A. Phipps, Michele Ellender

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The absorption kinetics for uranium into blood after deposition as tri-n-butylphosphate (UTBP) in the rat lung were combined with human data on particle deposition and clearance from the ICRP Publication 66 respiratory tract model and information from the most recent ICRP biokinetic model for uranium to predict the consequences for exposure of workers. These predictions suggest that, (1) the biokinetics of UTBP are similar to those for a Type F compound as defined by ICRP, (2) the dose coefficient is essentially independent of the aerosol size and isotopic composition, (3) the mass of uranium equivalent to the ALI can vary by 13 fold depending upon the isotopic composition, (4) intakes of uranium as UTBP other than chronic intakes as highly enriched forms should be restricted on the basis of the chemical toxicity of uranium, (5) the assessment of intake by urine bioassay measurements should be interpreted with caution unless the exposure conditions are well defined and (6) severe kidney damage is unlikely at intakes corresponding to the ALI or daily limit.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry Articles
Issue number1-2
Publication statusPublished - 1997

Bibliographical note

Funding Information:
We are indebted to K. WHrrCHR.L, S. LARDER and A. BIgOLr for expert help advice. This work was partially supported by the Commission of the European Communities under contract FI3P-CT920064a.


Dive into the research topics of 'Absorption kinetics of uranium tri-n-butyl phosphate in the rat: Implications for occupational exposure'. Together they form a unique fingerprint.

Cite this