A study of photobactericidal activity in the phenothiazinium series

M. Wainwright; D. A. Phoenix; J. Marland; D. R.A. Wareing; F. J. Bolton

doi:10.1016/S0928-8244(97)00070-9

A study of photobactericidal activity in the phenothiazinium series

M. Wainwright^*, D. A. Phoenix, J. Marland, D. R.A. Wareing, F. J. Bolton

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

155 Citations (Scopus)

Abstract

The photodynamic antibacterial properties of a closely related series of commercially available phenothiazinium dyes were tested against a range of pathogenic strains of Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative organisms (Escherichia coli, Pseudomonas aeruginosa). The photosensitisers were illuminated using a non-laser light source at a fluence of 1.75 mW cm^-2 and this resulted in the enhancement of antibacterial activity in liquid culture. In several cases, illumination resulted in considerable decreases in the minimum lethal concentrations required, giving up to 100-fold increases in bactericidal activity.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	FEMS Immunology and Medical Microbiology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/S0928-8244(97)00070-9
Publication status	Published - Sept 1997
Externally published	Yes

Keywords

Antibiacterial
Phenothiazinium
Photobactericide
Photodynamic action

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0928-8244(97)00070-9

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abstract = "The photodynamic antibacterial properties of a closely related series of commercially available phenothiazinium dyes were tested against a range of pathogenic strains of Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative organisms (Escherichia coli, Pseudomonas aeruginosa). The photosensitisers were illuminated using a non-laser light source at a fluence of 1.75 mW cm-2 and this resulted in the enhancement of antibacterial activity in liquid culture. In several cases, illumination resulted in considerable decreases in the minimum lethal concentrations required, giving up to 100-fold increases in bactericidal activity.",

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AU - Wareing, D. R.A.

AU - Bolton, F. J.

PY - 1997/9

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AB - The photodynamic antibacterial properties of a closely related series of commercially available phenothiazinium dyes were tested against a range of pathogenic strains of Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative organisms (Escherichia coli, Pseudomonas aeruginosa). The photosensitisers were illuminated using a non-laser light source at a fluence of 1.75 mW cm-2 and this resulted in the enhancement of antibacterial activity in liquid culture. In several cases, illumination resulted in considerable decreases in the minimum lethal concentrations required, giving up to 100-fold increases in bactericidal activity.

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KW - Phenothiazinium

KW - Photobactericide

KW - Photodynamic action

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JF - FEMS Immunology and Medical Microbiology

IS - 1

ER -

A study of photobactericidal activity in the phenothiazinium series

Abstract

Keywords

UN SDGs

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