A spatial joint analysis of metal constituents of ambient particulate matter and mortality in England

Aurore Lavigne, Anna Freni-Sterrantino, Daniela Fecht, Silvia Liverani, Marta Blangiardo, Kees De Hoogh, John Molitor, Anna L. Hansell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Few studies have investigated associations between metal components of particulate matter on mortality due to well-known issues of multicollinearity. Here, we analyze these exposures jointly to evaluate their associations with mortality on small area data. We fit a Bayesian profile regression (BPR) to account for the multicollinearity in the elemental components (iron, copper, and zinc) of PM10and PM2.5.The models are developed in relation to mortality from cardiovascular and respiratory disease and lung cancer incidence in 2008-2011 at a small area level, for a population of 13.6 million in the London-Oxford area of England. From the BPR, we identified higher risks in the PM10fraction cluster likely to represent the study area, excluding London, for cardiovascular mortality relative risk (RR) 1.07 (95% credible interval [CI] 1.02, 1.12) and for respiratory mortality RR 1.06 (95%CI 0.99, 1.31), compared with the study mean. For PM2.5fraction, higher risks were seen for cardiovascular mortality RR 1.55 (CI 95% 1.38, 1.71) and respiratory mortality RR 1.51 (CI 95% 1.33, 1.72), likely to represent the "highways" cluster. We did not find relevant associations for lung cancer incidence. Our analysis showed small but not fully consistent adverse associations between health outcomes and particulate metal exposures. The BPR approach identified subpopulations with unique exposure profiles and provided information about the geographical location of these to help interpret findings.

Original languageEnglish
Article numbere098
JournalEnvironmental Epidemiology
Issue number4
Publication statusPublished - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Wolters Kluwer Health. All rights reserved.


  • Bayesian profile regression
  • Clustering
  • Correlation
  • Multipollutant effect
  • Particulate matter elements


Dive into the research topics of 'A spatial joint analysis of metal constituents of ambient particulate matter and mortality in England'. Together they form a unique fingerprint.

Cite this