A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

Christian C. Abnet; Neal D. Freedman; Nan Hu; Zhaoming Wang; Kai Yu; Xiao Ou Shu; Jian Min Yuan; Wei Zheng; Sanford M. Dawsey; Linda M. Dong; Maxwell P. Lee; Ti Ding; You Lin Qiao; Yu Tang Gao; Woon Puay Koh; Yong Bing Xiang; Ze Zhong Tang; Jin Hu Fan; Chaoyu Wang; William Wheeler; Mitchell H. Gail; Meredith Yeager; Jeff Yuenger; Amy Hutchinson; Kevin B. Jacobs; Carol A. Giffen; Laurie Burdett; Joseph F. Fraumeni; Margaret A. Tucker; Wong Ho Chow; Alisa M. Goldstein; Stephen J. Chanock; Philip R. Taylor

doi:10.1038/ng.649

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

Christian C. Abnet^*
, Neal D. Freedman
, Nan Hu
, Zhaoming Wang
, Kai Yu
, Xiao Ou Shu
, Jian Min Yuan
, Wei Zheng
, Sanford M. Dawsey
, Linda M. Dong
, Maxwell P. Lee
, Ti Ding
, You Lin Qiao
, Yu Tang Gao
, Woon Puay Koh
, Yong Bing Xiang
, Ze Zhong Tang
, Jin Hu Fan
, Chaoyu Wang
, William Wheeler

Mitchell H. Gail, Meredith Yeager, Jeff Yuenger, Amy Hutchinson, Kevin B. Jacobs, Carol A. Giffen, Laurie Burdett, Joseph F. Fraumeni, Margaret A. Tucker, Wong Ho Chow, Alisa M. Goldstein, Stephen J. Chanock, Philip R. Taylor

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

458 Citations (Scopus)

Abstract

We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551, 152 SNPs. We report a combined analysis of 2, 240 gastric cancer cases, 2, 115 ESCC cases and 3, 302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10^-9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10^-9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10^-15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.

Original language	English
Pages (from-to)	764-768
Number of pages	5
Journal	Nature Genetics
Volume	42
Issue number	9
DOIs	https://doi.org/10.1038/ng.649
Publication status	Published - Sept 2010
Externally published	Yes

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10.1038/ng.649

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Abnet, C. C., Freedman, N. D., Hu, N., Wang, Z., Yu, K., Shu, X. O., Yuan, J. M., Zheng, W., Dawsey, S. M., Dong, L. M., Lee, M. P., Ding, T., Qiao, Y. L., Gao, Y. T., Koh, W. P., Xiang, Y. B., Tang, Z. Z., Fan, J. H., Wang, C., ... Taylor, P. R. (2010). A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nature Genetics, 42(9), 764-768. https://doi.org/10.1038/ng.649

@article{f96f4143763545ac9ac7524c8d56d185,

title = "A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma",

abstract = "We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551, 152 SNPs. We report a combined analysis of 2, 240 gastric cancer cases, 2, 115 ESCC cases and 3, 302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10-9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10-9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10-15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.",

author = "Abnet, \{Christian C.\} and Freedman, \{Neal D.\} and Nan Hu and Zhaoming Wang and Kai Yu and Shu, \{Xiao Ou\} and Yuan, \{Jian Min\} and Wei Zheng and Dawsey, \{Sanford M.\} and Dong, \{Linda M.\} and Lee, \{Maxwell P.\} and Ti Ding and Qiao, \{You Lin\} and Gao, \{Yu Tang\} and Koh, \{Woon Puay\} and Xiang, \{Yong Bing\} and Tang, \{Ze Zhong\} and Fan, \{Jin Hu\} and Chaoyu Wang and William Wheeler and Gail, \{Mitchell H.\} and Meredith Yeager and Jeff Yuenger and Amy Hutchinson and Jacobs, \{Kevin B.\} and Giffen, \{Carol A.\} and Laurie Burdett and Fraumeni, \{Joseph F.\} and Tucker, \{Margaret A.\} and Chow, \{Wong Ho\} and Goldstein, \{Alisa M.\} and Chanock, \{Stephen J.\} and Taylor, \{Philip R.\}",

year = "2010",

month = sep,

doi = "10.1038/ng.649",

language = "English",

volume = "42",

pages = "764--768",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "9",

}

Abnet, CC, Freedman, ND, Hu, N, Wang, Z, Yu, K, Shu, XO, Yuan, JM, Zheng, W, Dawsey, SM, Dong, LM, Lee, MP, Ding, T, Qiao, YL, Gao, YT, Koh, WP, Xiang, YB, Tang, ZZ, Fan, JH, Wang, C, Wheeler, W, Gail, MH, Yeager, M, Yuenger, J, Hutchinson, A, Jacobs, KB, Giffen, CA, Burdett, L, Fraumeni, JF, Tucker, MA, Chow, WH, Goldstein, AM, Chanock, SJ & Taylor, PR 2010, 'A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma', Nature Genetics, vol. 42, no. 9, pp. 764-768. https://doi.org/10.1038/ng.649

TY - JOUR

T1 - A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

AU - Abnet, Christian C.

AU - Freedman, Neal D.

AU - Hu, Nan

AU - Wang, Zhaoming

AU - Yu, Kai

AU - Shu, Xiao Ou

AU - Yuan, Jian Min

AU - Zheng, Wei

AU - Dawsey, Sanford M.

AU - Dong, Linda M.

AU - Lee, Maxwell P.

AU - Ding, Ti

AU - Qiao, You Lin

AU - Gao, Yu Tang

AU - Koh, Woon Puay

AU - Xiang, Yong Bing

AU - Tang, Ze Zhong

AU - Fan, Jin Hu

AU - Wang, Chaoyu

AU - Wheeler, William

AU - Gail, Mitchell H.

AU - Yeager, Meredith

AU - Yuenger, Jeff

AU - Hutchinson, Amy

AU - Jacobs, Kevin B.

AU - Giffen, Carol A.

AU - Burdett, Laurie

AU - Fraumeni, Joseph F.

AU - Tucker, Margaret A.

AU - Chow, Wong Ho

AU - Goldstein, Alisa M.

AU - Chanock, Stephen J.

AU - Taylor, Philip R.

PY - 2010/9

Y1 - 2010/9

N2 - We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551, 152 SNPs. We report a combined analysis of 2, 240 gastric cancer cases, 2, 115 ESCC cases and 3, 302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10-9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10-9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10-15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.

AB - We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551, 152 SNPs. We report a combined analysis of 2, 240 gastric cancer cases, 2, 115 ESCC cases and 3, 302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10-9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10-9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10-15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.

UR - https://www.scopus.com/pages/publications/77956623860

U2 - 10.1038/ng.649

DO - 10.1038/ng.649

M3 - Letter

C2 - 20729852

AN - SCOPUS:77956623860

SN - 1061-4036

VL - 42

SP - 764

EP - 768

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

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