A sensitive chromogenic limulus amoebocyte lysate micro-assay for detection of endotoxin in human plasma and in water

Boguslawa I. Piotrowicz*, S. E. Edlin, A. Christine McCartney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This chromogenic endotoxin assay involves a 45 min incubation of plasma extract or water with a mixture of Limulus amoebocyte lysate and the chromogenic substrate S-2423. Absorbance is measured in micro-titre plates. The assay allows the detection of 0.2 pg endotoxin per ml in water (0.002 Endotoxin Units/ml) and 1 pg endotoxin per ml in plasma (0.012 Endotoxin Units/ml). The intra-assay coefficient of variation is less than 5%.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalZentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A
Volume260
Issue number1
DOIs
Publication statusPublished - 1985
Externally publishedYes

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